Publication:
Heart-Breaking Telomeres.

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dc.contributor.authorBlasco, MA
dc.contributor.authorMartinez Rodriguez, Paula
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderFundación Banco Santander
dc.date.accessioned2024-02-28T10:40:17Z
dc.date.available2024-02-28T10:40:17Z
dc.date.issued2018-09-14
dc.description.abstractTelomeres, the protective ends of linear chromosomes, shorten throughout an individual's lifetime. Accumulation of critically short telomeres is proposed to be a primary molecular cause of aging and age-associated diseases. Mutations in telomere maintenance genes are associated with pathologies referred to as or telomeropathies. The rate of telomere shortening throughout life is determined by endogenous (genetic) and external (nongenetic) factors. Therapeutic strategies based on telomerase activation are being developed to treat and prevent telomere-associated diseases, namely aging-related diseases and telomeropathies. Here, we review the molecular mechanisms underlying telomere driven diseases with particular emphasis on cardiovascular diseases.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipResearch in the Blasco laboratory is funded by project SAF2013-5111-R of Societal Changes Program of the Spanish Ministry of Economics and Competitiveness cofinanced through the European Fund of Regional Development and Fundacion Botin, Banco Santander (Santander Universities Global Division).es_ES
dc.format.number7es_ES
dc.format.page787es_ES
dc.format.volume123es_ES
dc.identifier.citationCirc Res . 2018 ;123(7):787-802es_ES
dc.identifier.doi10.1161/CIRCRESAHA.118.312202es_ES
dc.identifier.e-issn1524-4571es_ES
dc.identifier.journalCirculation researches_ES
dc.identifier.pubmedID30355079es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18861
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkins (LWW)
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/SAF2013-5111-Res_ES
dc.relation.publisherversionhttps://doi.org/10.1161/CIRCRESAHA.118.312202.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Telómeros y Telomerasaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshCardiovascular Systemes_ES
dc.subject.meshTelomere Shorteninges_ES
dc.subject.meshAge Factorses_ES
dc.subject.meshAginges_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCardiovascular Diseaseses_ES
dc.subject.meshGenetic Predisposition to Diseasees_ES
dc.subject.meshHumanses_ES
dc.subject.meshPhenotypees_ES
dc.subject.meshRisk Factorses_ES
dc.subject.meshTelomerees_ES
dc.subject.meshTelomere Homeostasises_ES
dc.titleHeart-Breaking Telomeres.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
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