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Vpu Protein: The Viroporin Encoded by HIV-1

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dc.contributor.authorGonzalez Portal, Maria Eugenia
dc.contributor.funderInstituto de Salud Carlos III
dc.date.accessioned2018-03-21T11:13:23Z
dc.date.available2018-03-21T11:13:23Z
dc.date.issued2015-08-04
dc.description.abstractViral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. Notwithstanding the high variability of its amino acid sequence, the functionality of Vpu is well conserved in pandemic virus isolates. This review outlines our current knowledge on the interactions of Vpu with the host cell. The regulation of cellular physiology by Vpu and the validity of this viroporin as a therapeutic target are also discussed.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by grant PI08/0912 from FIS.es_ES
dc.format.number8es_ES
dc.format.page4352-68es_ES
dc.format.volume7es_ES
dc.identifier.citationViruses. 2015;7(8):4352-68es_ES
dc.identifier.doi10.3390/v7082824es_ES
dc.identifier.e-issn1999-4915es_ES
dc.identifier.issn1999-4915es_ES
dc.identifier.journalViruseses_ES
dc.identifier.pubmedID26247957es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5773
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.publisherMolecular Diversity Preservation Internationales_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0912es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/v7082824es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHIV-1es_ES
dc.subjectViroporines_ES
dc.subjectVpues_ES
dc.subjectAntiretroviral targetes_ES
dc.subjectIon transportes_ES
dc.subjectMembrane permeabilityes_ES
dc.subjectMembrane porees_ES
dc.subjectProtein traffickinges_ES
dc.titleVpu Protein: The Viroporin Encoded by HIV-1es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationbd55b7e0-7523-4dc6-83da-c9edd512d078
relation.isAuthorOfPublication.latestForDiscoverybd55b7e0-7523-4dc6-83da-c9edd512d078

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