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Capsule switching among C:2b:P1.2,5 meningococcal epidemic strains after mass immunization campaign, Spain

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URI: http://hdl.handle.net/20.500.12105/6993
ISSN: 1080-6040
DOI: 10.3201/eid0812.020081

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2002-12

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Abstract

A mass immunization campaign for 18-month to 19-year-olds was undertaken in Spain in 1996-1997 because of an epidemic of serogroup C meningococcal disease associated with a C:2b:P1.2,5 strain belonging to the A4 lineage. Surveillance for the "capsule-switching" phenomenon producing B:2b:P1.2,5 isolates was undertaken. Of 2,975 meningococci characterized, B:2b:P1.2,5 and B:2b:P1.2 antigenic combinations were found in 18 isolates; 15 meningococci were defined as serogroup B belonging to the A4 lineage.

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Adolescent Adult Bacterial Capsules Child Child, Preschool Electrophoresis, Gel, Pulsed-Field Humans Infant Mass Vaccination Meningitis, Meningococcal Polysaccharides, Bacterial Spain

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Emerg Infect Dis. 2002;8(12):1512-4.

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Centro Nacional de Microbiología (CNM)

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https://doi.org/10.3201/eid0812.020081

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research article