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DNA Methylation Changes are Associated with the Programming of White Adipose Tissue Browning Features by Resveratrol and Nicotinamide Riboside Neonatal Supplementations in Mice

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dc.contributor.authorSerrano, Alba
dc.contributor.authorAsnani-Kishnani, Madhu
dc.contributor.authorCouturier, Charlene
dc.contributor.authorAstier, Julien
dc.contributor.authorPalou, Andreu
dc.contributor.authorLandrier, Jean-Francois
dc.contributor.authorRibot, Joan
dc.contributor.authorBonet, M Luisa
dc.date.accessioned2024-09-13T09:14:37Z
dc.date.available2024-09-13T09:14:37Z
dc.date.issued2020-02
dc.description.abstractNeonatal supplementation with resveratrol (RSV) or nicotinamide riboside (NR) programs in male mice brown adipocyte-like features in white adipose tissue (WAT browning) together with improved metabolism in adulthood. We tested the involvement in this programming of long-term epigenetic changes in two browning-related genes that are overexpressed inWAT of supplemented mice, Slc27a1 and Prdm16. Suckling mice received orally the vehicle, RSV or NR from postnatal days 2-to-20. After weaning (d21) onto a chow diet, male mice were habituated to a normal-fat diet (NFD) starting d75, and split on d90 into continuation on the NFD or switching to a high-fat diet (HFD) until euthanization on d164. CpG methylation by bisulfite-sequencing was analyzed on inguinal WAT. Both treatments modified methylation marks in Slc27a1 and Prdm16 and the HFD-dependent dynamics of these marks in the adultWAT, with distinct and common effects. The treatments also a ffected gene expression of de novo DNA methylases in WAT of young animals (euthanized at d35 in independent experiments). Studies in 3T3-L1 adipocytes indicated the direct effects of RSV and NR on the DNA methylation machinery and favoring browning features. The results support epigenetic effects being involved inWAT programming by neonatal RSV or NR supplementation in male mice.en
dc.description.sponsorshipThis work was supported by the Spanish Government (MICIU, AEI, Fondo FEDER/EU) under PGC2018-097436-B-I00 (to A.P.) and Fundacion Ramon Areces under a XVI Concurso Nacional para la Adjudicacion de Ayudas a la Investigacion Cientifica y Tecnica grant (to M.L.B). Our group is a member of the European Nutrigenomics Organization (NuGO). A.S. acknowledges support received from COST-Action EUROCAROTEN (CA15136; EU Framework Programme Horizon 2020) through a Short-Term Scientific Mission at the INRA-INSERM at Aix-Marseille University (France). CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) is an initiative of the ISCIII (Spanish Government).es_ES
dc.format.number2es_ES
dc.format.page461es_ES
dc.format.volume12es_ES
dc.identifier.citationSerrano A, Asnani-Kishnani Madhu, Couturier C, Astier J, Palou A, Landrier JF, et al. DNA Methylation Changes are Associated with the Programming of White Adipose Tissue Browning Features by Resveratrol and Nicotinamide Riboside Neonatal Supplementations in Mice. Nutrients. 2020 Feb;12(2):461.en
dc.identifier.doi10.3390/nu12020461
dc.identifier.e-issn2072-6643es_ES
dc.identifier.journalNutrientses_ES
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/11909
dc.identifier.pubmedID32059412es_ES
dc.identifier.puiL2003765660
dc.identifier.scopus2-s2.0-85079484359
dc.identifier.urihttps://hdl.handle.net/20.500.12105/22944
dc.identifier.wos522458700188
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://dx.doi.org/10.3390/nu12020461en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDNA methylation
dc.subjectMetabolic programming
dc.subjectWAT beiging/browning
dc.subjectFood bioactives
dc.subjectB vitamins
dc.subjectDietary polyphenols
dc.subject.decsAnimales*
dc.subject.decsEpigénesis Genética*
dc.subject.decsCélulas 3T3-L1*
dc.subject.decsMasculino*
dc.subject.decsAdministración Oral*
dc.subject.decsTejido Adiposo Pardo*
dc.subject.decsTejido Adiposo Blanco*
dc.subject.decsNiacinamida*
dc.subject.decsAnimales Recién Nacidos*
dc.subject.decsMetilación de ADN*
dc.subject.decsResveratrol*
dc.subject.decsRatones*
dc.subject.decsSuplementos Dietéticos*
dc.subject.decsFenómenos Fisiológicos Nutricionales de los Animales*
dc.subject.meshAnimals, Newborn*
dc.subject.meshAnimal Nutritional Physiological Phenomena*
dc.subject.meshDNA Methylation*
dc.subject.mesh3T3-L1 Cells*
dc.subject.meshAdministration, Oral*
dc.subject.meshResveratrol*
dc.subject.meshNiacinamide*
dc.subject.meshAdipose Tissue, Brown*
dc.subject.meshEpigenesis, Genetic*
dc.subject.meshMale*
dc.subject.meshAnimals*
dc.subject.meshAdipose Tissue, White*
dc.subject.meshDietary Supplements*
dc.subject.meshMice*
dc.titleDNA Methylation Changes are Associated with the Programming of White Adipose Tissue Browning Features by Resveratrol and Nicotinamide Riboside Neonatal Supplementations in Miceen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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