Publication: Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.
No Thumbnail Available
Identifiers
Publication date
2018-09-11
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Export
Abstract
Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p
Description
Keywords
MeSH Terms
Cholesterol Cholesterol, HDL Cholesterol, LDL Female Fetal Growth Retardation Fetus Humans Lipid Metabolism Lipids Lipoproteins Lipoproteins, HDL Lipoproteins, VLDL Male Metabolome Mothers Pregnancy Triglycerides
DeCS Terms
Bibliographic citation
Publisher version
Document type
research article