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Mechanisms of metabolic dysfunction in cancer-associated cachexia

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dc.contributor.authorPetruzzelli, Michele
dc.contributor.authorWagner, Erwin Friedrich
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.date.accessioned2019-07-10T09:01:38Z
dc.date.available2019-07-10T09:01:38Z
dc.date.issued2016-03-01
dc.description.abstractMetabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipWe are very grateful to Dr. Doug Hanahan, Dr. Anna Hupalow- ska, Dr. Graham Robertson, Dr. Martina Schweiger, Dr. Marta Shahbazi, Dr. Rudolf Zechner, and our laboratory colleagues Dr. Latifa Bakiri, Dr. Oezge Uluckan, and Dr. Sebastian Hasen- fuss for critical reading and comments on our manuscript. E.F. W. is supported by a grant from the Spanish Ministry of Economy (BFU2012-40230) and a European Research Council Advanced Grant (ERC FCK/2008/37)es_ES
dc.format.number5es_ES
dc.format.page489-501es_ES
dc.format.volume30es_ES
dc.identifier.citationGenes Dev. 2016;30(5):489-501.es_ES
dc.identifier.doi10.1101/gad.276733.115es_ES
dc.identifier.e-issn1549-5477es_ES
dc.identifier.issn0890-9369es_ES
dc.identifier.journalGenes & developmentes_ES
dc.identifier.pubmedID26944676es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7878
dc.language.isoenges_ES
dc.publisherCold Spring Harbor Laboratory Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2012-40230es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FCK/2008/37es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/ 10.1101/gad.276733.115.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Genes, Desarrollo y Enfermedades_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectcancer-associated cachexia (CAC)es_ES
dc.subjectmetabolic failurees_ES
dc.subjectskeletal muscle atrophyes_ES
dc.subjectwhite adipose tissue (WAT) browninges_ES
dc.subject.meshAdipose Tissue, Whitees_ES
dc.subject.meshCachexiaes_ES
dc.subject.meshCarbohydrate Metabolismes_ES
dc.subject.meshEndocrine Systemes_ES
dc.subject.meshHumanses_ES
dc.subject.meshInflammationes_ES
dc.subject.meshLipid Metabolismes_ES
dc.subject.meshLiveres_ES
dc.subject.meshMuscular Atrophyes_ES
dc.subject.meshNeoplasmses_ES
dc.titleMechanisms of metabolic dysfunction in cancer-associated cachexiaes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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