Publication: Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy
dc.contributor.author | Pérez-Romero, Karim | |
dc.contributor.author | Rodriguez, Ramon M | |
dc.contributor.author | Amedei, Amedeo | |
dc.contributor.author | Barcelo-Coblijn, Gwendolyn | |
dc.contributor.author | Lopez, Daniel H | |
dc.date.accessioned | 2024-09-13T09:14:50Z | |
dc.date.available | 2024-09-13T09:14:50Z | |
dc.date.issued | 2020-08 | |
dc.description.abstract | Integration of the tumor microenvironment as a fundamental part of the tumorigenic process has undoubtedly revolutionized our understanding of cancer biology. Increasing evidence indicates that neoplastic cells establish a dependency relationship with normal resident cells in the affected tissue and, furthermore, develop the ability to recruit new accessory cells that aid tumor development. In addition to normal stromal and tumor cells, this tumor ecosystem includes an infiltrated immune component that establishes complex interactions that have a critical effect during the natural history of the tumor. The process by which immune cells modulate tumor progression is known as immunoediting, a dynamic process that creates a selective pressure that finally leads to the generation of immune-resistant cells and the inability of the immune system to eradicate the tumor. In this context, the cellular and functional characterization of the immune compartment within the tumor microenvironment will help to understand tumor progression and, ultimately, will serve to create novel prognostic tools and improve patient stratification for cancer treatment. Here we review the impact of the immune system on tumor development, focusing particularly on its clinical implications and the current technologies used to analyze immune cell diversity within the tumor. | en |
dc.description.sponsorship | This research was funded by the Institute of Health Carlos III, grant number PI19/00002 and PI19/00184, the Spanish Association Against Cancer (AECC-Junta de Baleares), grant number AECC02-2017, and the Direccio General de Innovacio i Recerca (Government of the Balearic Islands), grant number AAEE021/2017 and cofounded by ERDF (European Regional Development Fund). RMR contract is supported by the MINECO (Juan de la Cierva-Incorporacion, grant number IJCI-2017-33347), and the DHL contract is supported by the Institute of Health Carlos III (GIS19/00018) and cofunded by ESF (European Social Fund). | es_ES |
dc.format.number | 15 | es_ES |
dc.format.page | 5521 | es_ES |
dc.format.volume | 21 | es_ES |
dc.identifier.citation | Pérez Romero K, Rodriguez RM, Amedei A, Barceló-Coblijn G, Lopez DH. Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy. Int J Mol Sci. 2020 Aug;21(15):5521. | en |
dc.identifier.doi | 10.3390/ijms21155521 | |
dc.identifier.e-issn | 1422-0067 | es_ES |
dc.identifier.journal | International Journal of Molecular Sciences | es_ES |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9953 | |
dc.identifier.pubmedID | 32752264 | es_ES |
dc.identifier.pui | L2004837291 | |
dc.identifier.scopus | 2-s2.0-85088963519 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12105/22985 | |
dc.identifier.wos | 559093400001 | |
dc.language.iso | eng | en |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en |
dc.relation.publisherversion | https://dx.doi.org/10.3390/ijms21155521 | en |
dc.rights.accessRights | open access | en |
dc.rights.license | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Tumor microenvironment | |
dc.subject | Immune response | |
dc.subject | Immunomodulation | |
dc.subject.decs | Sistema Inmunológico | * |
dc.subject.decs | Comunicación Celular | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Células Madre Neoplásicas | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Neoplasias | * |
dc.subject.decs | Pronóstico | * |
dc.subject.decs | Inmunoterapia | * |
dc.subject.decs | Biomarcadores de Tumor | * |
dc.subject.decs | Microambiente Tumoral | * |
dc.subject.mesh | Prognosis | * |
dc.subject.mesh | Tumor Microenvironment | * |
dc.subject.mesh | Immunotherapy | * |
dc.subject.mesh | Biomarkers, Tumor | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Immune System | * |
dc.subject.mesh | Cell Communication | * |
dc.subject.mesh | Neoplasms | * |
dc.subject.mesh | Neoplastic Stem Cells | * |
dc.title | Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy | en |
dc.type | review article | en |
dspace.entity.type | Publication |