Publication:
Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia

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dc.contributor.authorJember, Tadesse Hailu
dc.contributor.authorAmor, Arancha
dc.contributor.authorNibret, Endalkachew
dc.contributor.authorMunshea, Abaineh
dc.contributor.authorFlores-Chavez, Maria
dc.contributor.authorTa Tang, Thuy-Huong
dc.contributor.authorSaugar, Jose Maria
dc.contributor.authorBenito, Agustin
dc.contributor.authorAnegagrie, Melaku
dc.contributor.funderBahir Dar University (Etiopía)es_ES
dc.contributor.funderFundación Mundo Sanoes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.date.accessioned2022-11-15T08:45:25Z
dc.date.available2022-11-15T08:45:25Z
dc.date.issued2022-04-28
dc.description.abstractBackground: Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. stercoralis in Ethiopia is underestimated due to the lack of a "Gold" standard diagnostic method. Moreover, its prevalence across altitudinal gradient in Amhara Region has not been studied. Methods: A cross-sectional study was conducted among 844 schoolchildren in Amhara Region from April to December 2019. A stool sample was collected from each study participant and processed using formol ether concentration technique (FECT), spontaneous tube sedimentation technique (STST), Baermann concentration technique (BCT), agar plate culture (APC) and real-time polymerase chain reaction (RT-PCR). Data were entered using EpiData and analyzed by SPSS version 23 statistical software. Prevalence of S. stercoralis infection was determined using a single diagnostic technique and combination of techniques. Association of clinical variables with S. stercoralis infection was assessed by logistic regression and independent variables with p<0.05 were considered statistically significant. Results: Prevalence of soil-transmitted helminths (STHs) and S. mansoni infections was 38.0% and 20.4%, respectively. Among STHs, the prevalence of hookworm infection was 32.8%. Prevalence of S. stercoralis infection was 39.0%, 28.8%, 10.9%, 10.3%, 4.0% and 2.0% by the respective, combinations of the five methods, RT-PCR, APC, BCT, STST and FECT. The highest prevalence rates, 48.2%, 45.0% and 41.1% of S. stercoralis were recorded in the age group of 12-14 years, males and rural dwellers, respectively. Prevalence rates of S. stercoralis infection in highland, semi-highland and lowland areas were 40.4%, 41.8% and 25.9%, respectively. Having abdominal pain (AOR = 2.48; 95% CI:1.65-3.72), cough (AOR = 1.63;95%CI:1.09-2.42), urticaria (AOR = 2.49;95%CI:1.50-4.01) and being malnourished (AOR = 1.44;95%:1.10-2.01) were significantly associated with strongyloidiasis. Conclusion: Prevalence of S. stercoralis infection was high and varied across different altitudes in Amhara Region. Some clinical syndromes were found to be significantly associated with S. stercoralis infection. Therefore, proper diagnosis and preventive strategies against S. stercoralis infection are highly recommended to be devised and implemented in Amhara Region.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis study was funded by the Bahir Dar University (https://www.bdu.edu.et), Mundo Sano Foundation (https://www.mundosano.org/es/) and the National Center of Tropical Medicine, from the Institute of Health Carlos III (https://www.isciii.es/QuienesSomos/CentrosPropios/CNMT/Paginas/default.aspx), which supported the implementation by providing material support. We received materials and reagents but not a specific budget from funders to this project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.format.number4es_ES
dc.format.pagee0010299es_ES
dc.format.volume16es_ES
dc.identifier.citationPLoS Negl Trop Dis. 2022 Apr 28;16(4):e0010299.es_ES
dc.identifier.doi10.1371/journal.pntd.0010299es_ES
dc.identifier.e-issn1935-2735es_ES
dc.identifier.journalPLoS neglected tropical diseaseses_ES
dc.identifier.pubmedID35482629es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15133
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS)es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pntd.0010299es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Medicina Tropicales_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.meshStrongyloides stercoralises_ES
dc.subject.meshStrongyloidiasises_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAltitudees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshChildes_ES
dc.subject.meshCross-Sectional Studieses_ES
dc.subject.meshEthiopiaes_ES
dc.subject.meshFeceses_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshPrevalencees_ES
dc.titlePrevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopiaes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication2036bb40-097f-406a-b634-f77164674c2b
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relation.isAuthorOfPublication.latestForDiscoveryf7f5ae06-0e03-4f0c-9ec3-b1afd845f525
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