Publication:
Retinoid X receptors in macrophage biology

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dc.contributor.authorRoszer, Tamas
dc.contributor.authorMenendez-Gutierrez, Maria Piedad
dc.contributor.authorCedenilla, Marta
dc.contributor.authorRicote, Mercedes
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderEuropean Foundation for the Study of Diabetes
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderFundación ProCNIC
dc.date.accessioned2020-05-05T08:49:52Z
dc.date.available2020-05-05T08:49:52Z
dc.date.issued2013-09
dc.description.abstractRetinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism. Recent advances reveal that RXRs are important regulators of macrophages, key players in inflammatory and metabolic disorders. This review outlines the versatility of RXR action in the control of macrophage gene transcription through its heterodimerization with other NRs or through RXR homodimerization. We also highlight the potential of RXR-controlled transcriptional programs as targets for the treatment of pathologies associated with altered macrophage function, such as atherosclerosis, insulin resistance, autoimmunity, and neurodegeneration.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipWork performed in the laboratory of the authors was funded by awards from the Spanish Ministry of Economy and Competitiveness (SAF201231483) to M.R., a European Foundation for the Study of Diabetes–Lilly Fellowship Program to T.R., and a Spanish Ministry of Science, and Innovation (FPU, AP2008-00508) grant to M.C. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation.es_ES
dc.format.number9es_ES
dc.format.page460-8es_ES
dc.format.volume24es_ES
dc.identifier.citationTrends Endocrinol Metab. 2013; 24(9):460-8es_ES
dc.identifier.doi10.1016/j.tem.2013.04.004es_ES
dc.identifier.e-issn1879-3061es_ES
dc.identifier.issn1043-2760es_ES
dc.identifier.journalTrends in endocrinology and metabolism: TEMes_ES
dc.identifier.pubmedID23701753es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9882
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.tem.2013.04.004es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización de los Receptores Nucleareses_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGene transcriptiones_ES
dc.subjectInflammationes_ES
dc.subjectLipid metabolismes_ES
dc.subjectMacrophagees_ES
dc.subjectNuclear receptorses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshHumanses_ES
dc.subject.meshImmunity, Innatees_ES
dc.subject.meshMacrophageses_ES
dc.subject.meshRetinoid X Receptorses_ES
dc.titleRetinoid X receptors in macrophage biologyes_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublicationde41517f-d151-4bb6-8cf3-44f28ec51849
relation.isAuthorOfPublication.latestForDiscovery3935105f-ad3b-4f0d-94e7-17405a0b8149

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