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Selected reaction monitoring assays in mesenchymal stem cells from osteoarthritis patients

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dc.contributor.authorCamafeita, Emilio
dc.contributor.authorLamas, José Ramón
dc.contributor.authorCalvo, Enrique
dc.contributor.authorTornero-Esteban, Pilar
dc.contributor.authorLopez, Juan Antonio
dc.contributor.authorFernandez-Gutierrez, Benjamin
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderFundación ProCNIC
dc.date.accessioned2019-04-29T12:33:40Z
dc.date.available2019-04-29T12:33:40Z
dc.date.issued2014
dc.description.abstractOsteoarthritis (OA) is considered the most prevalent form of arthritis. The aim of this study was to verify potential protein OA biomarkers by applying Selected Reaction Monitoring (SRM) assays to protein extracts obtained from Bone Marrow-Mesenchymal Stem Cells (BM-MSCs) isolated from OA patients. BM aspirates were obtained from the femoral channel of OA patients at the time of surgery and from the femoral channel of hip fracture subjects without OA during hip joint replacement surgery for the treatment of subcapital fracture. SRM results verified the differential expression of several protein biomarkers in BM-MSCs from OA patients.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipCNIC is supported by the Ministerio de Economía y Competitividad and the Fundación Pro CNIC. Support was also provided by FIS PI10/00178 and RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII). JRL is a recipient of Miguel Servet Program from Instituto de Salud Carlos III (ISCIII).es_ES
dc.format.number1es_ES
dc.format.page33es_ES
dc.format.volume11es_ES
dc.identifier.citationClin Proteomics. 2014; 11(1):33es_ES
dc.identifier.doi10.1186/1559-0275-11-33es_ES
dc.identifier.issn1542-6416es_ES
dc.identifier.journalClinical proteomicses_ES
dc.identifier.pubmedID25249828es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7533
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD08/0075es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómicaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMesenchymal stem cellses_ES
dc.subjectOsteoarthritises_ES
dc.subjectSelected reaction monitoringes_ES
dc.titleSelected reaction monitoring assays in mesenchymal stem cells from osteoarthritis patientses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication620c7d10-2b0e-45a4-a556-9f84b9d6df64
relation.isAuthorOfPublication38fcf75a-f030-4879-ae7a-a697cff3c329
relation.isAuthorOfPublicationd79f2bf1-6f13-4b5f-9ae3-4c0ea06e9dcb
relation.isAuthorOfPublication.latestForDiscovery620c7d10-2b0e-45a4-a556-9f84b9d6df64

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