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Dermatophagoides pteronyssinus immunotherapy changes the T-regulatory cell activity.

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dc.contributor.authorGonzalez, M
dc.contributor.authorDoña, I
dc.contributor.authorPalomares, F
dc.contributor.authorCampo, P
dc.contributor.authorRodriguez, M J
dc.contributor.authorRondon, C
dc.contributor.authorGomez, F
dc.contributor.authorFernandez, T D
dc.contributor.authorPerkins, J R
dc.contributor.authorEscribese, M M
dc.contributor.authorTorres, M J
dc.contributor.authorMayorga, C
dc.date.accessioned2024-01-23T20:13:07Z
dc.date.available2024-01-23T20:13:07Z
dc.date.issued2017-09-20
dc.description.abstractSubcutaneous specific immunotherapy (SCIT) has been shown to modify the Dermatophagoides pteronissinus (DP) allergic response, characterized by generation of Treg cells. However, studies have reported no changes in the proportion of Treg cells after immunotherapy, indicating that the effects may be due to modifications in their regulatory activities. We aimed to determine whether Tregs generated by DP-SCIT can switch the allergic response to tolerant and study the involvement of suppressive cytokines on it. Twenty-four DP-allergic rhinitis patients were recruited, 16 treated with DP-SCIT and 8 untreated. Treg and T effector cells were isolated before and after DP-SCIT, and cocultured in different combinations with α-IL-10, α-TGF-β blocking antibodies and nDer p 1. Treg cells after DP-SCIT increased Th1 and decreased Th2 and Th9 proliferation. Similarly, they increased IL-10 and decreased IL-4 and IL-9-producing cells. α-IL-10 affected the activity of Treg cells obtained after DP-SCIT only. Finally, DP-specific IgG4 levels, Treg percentage and IL-10 production were correlated after DP-SCIT. These results demonstrate that DP-SCIT induces Treg cells with different suppressive activities. These changes could be mediated by IL-10 production and appear to play an important role in the induction of the tolerance response leading to a clinical improvement of symptoms.
dc.format.number1es_ES
dc.format.page11949es_ES
dc.format.volume7es_ES
dc.identifier.doi10.1038/s41598-017-12261-2
dc.identifier.e-issn2045-2322es_ES
dc.identifier.journalScientific reportses_ES
dc.identifier.otherhttp://hdl.handle.net/10668/11598
dc.identifier.pubmedID28931869es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17333
dc.language.isoeng
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdult
dc.subject.meshAnimals
dc.subject.meshAntigens, Dermatophagoides
dc.subject.meshCells, Cultured
dc.subject.meshCoculture Techniques
dc.subject.meshDermatophagoides pteronyssinus
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunotherapy
dc.subject.meshInjections, Subcutaneous
dc.subject.meshMale
dc.subject.meshRhinitis, Allergic
dc.subject.meshT-Lymphocytes, Regulatory
dc.subject.meshTh1 Cells
dc.subject.meshTh2 Cells
dc.subject.meshYoung Adult
dc.titleDermatophagoides pteronyssinus immunotherapy changes the T-regulatory cell activity.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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