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Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

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dc.contributor.authorAguado-Garcia, Diana
dc.contributor.authorOlvera, Alex
dc.contributor.authorBrander, Christian
dc.contributor.authorSanchez-Merino, Victor
dc.contributor.authorYuste, Eloisa
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderRed de Investigación Cooperativa en Investigación en Sida (España)es_ES
dc.contributor.funderPlan Nacional de I+D+i (España)es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderUnión Europea. Comisión Europea. H2020es_ES
dc.date.accessioned2022-11-18T13:29:55Z
dc.date.available2022-11-18T13:29:55Z
dc.date.issued2022-03-22
dc.description.abstractThe long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle tracking analysis (NTA), and enzyme-linked immunoabsorbent assay (ELISA) results demonstrated a remarkable structural stability. VLPs maintained their integrity and the recognition of relevant B-cell epitopes for three months at 4 and -20 °C. Interestingly, most particles remained intact and preserved the recognition of relevant epitopes even after a week of storage at room temperature.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis research was funded by Instituto de Salud Carlos III within the Spanish AIDS Research Network (RIS), grant number RD16CIII/0002/0001 (Plan Estatal de I + D + I 2013-2016) and cofunded by European Regional Development Fund (ERDF) “A way to build Europe”. This study was also supported by the Spanish Ministry of Science, Innovation and University, Instituto de Salud Carlos III [PI17CIII-00049 (MPY126/18)] and the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III [PI20CIII-00039 (MPY315/20)]. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 681137 (EAVI-2020).es_ES
dc.format.number4es_ES
dc.format.page484es_ES
dc.format.volume10es_ES
dc.identifier.citationVaccines (Basel). 2022 Mar 22;10(4):484.es_ES
dc.identifier.doi10.3390/vaccines10040484es_ES
dc.identifier.issn2076-393Xes_ES
dc.identifier.journalVaccineses_ES
dc.identifier.pubmedID35455233es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15192
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/RD16CIII/0002/0001es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI17CIII-00049es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY126/18es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI20CIII-00039es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY315/20es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/681137/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/vaccines10040484es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectVirus-like particleses_ES
dc.subjectHIVes_ES
dc.subjectVaccinees_ES
dc.subjectThermostabilityes_ES
dc.titleEvaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelopees_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication2c8533e8-d63c-4c22-9a9b-b630525f7153
relation.isAuthorOfPublication1e723484-61b4-4f8f-ad19-48873c9050f5
relation.isAuthorOfPublication.latestForDiscovery2c8533e8-d63c-4c22-9a9b-b630525f7153

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