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G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate

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dc.contributor.authorRodero, Laura
dc.contributor.authorMellado, Emilia
dc.contributor.authorRodríguez, A Carolina
dc.contributor.authorSalve, Angela
dc.contributor.authorGuelfand, Liliana
dc.contributor.authorCahn, Pedro
dc.contributor.authorCuenca-Estrella, Manuel
dc.contributor.authorDavel, Graciela
dc.contributor.authorRodriguez-Tudela, Juan Luis
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)
dc.date.accessioned2019-08-13T12:22:21Z
dc.date.available2019-08-13T12:22:21Z
dc.date.issued2003-11
dc.description.abstractFive sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.es_ES
dc.description.sponsorshipWe thank the Biopolymers Unit at Instituto de Salud Carlos III, Majadahonda, Madrid, Spain, for DNA sequencing and Sylvia Spitzer for providing the CNRE-1 repetitive probe. E.M. held a contract Ramon y Cajal from Ministry of Science and Technology. L.R. held a grant from PAHO and ISCIII. L.R. and E.M. contributed equally to this work.es_ES
dc.format.number11es_ES
dc.format.page3653-6es_ES
dc.format.volume47es_ES
dc.identifier.citationAntimicrob Agents Chemother. 2003 Nov;47(11):3653-6.es_ES
dc.identifier.doi10.1128/aac.47.11.3653-3656.2003es_ES
dc.identifier.issn0066-4804es_ES
dc.identifier.journalAntimicrobial agents and chemotherapyes_ES
dc.identifier.pubmedID14576140es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8247
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiology (ASM)
dc.relation.publisherversionhttps://doi.org/10.1128/aac.47.11.3653-3656.2003es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAcquired Immunodeficiency Syndromees_ES
dc.subject.meshAdultes_ES
dc.subject.meshAmino Acid Sequencees_ES
dc.subject.meshAmino Acid Substitutiones_ES
dc.subject.meshAntifungal Agentses_ES
dc.subject.meshCloning, Moleculares_ES
dc.subject.meshCryptococcus neoformanses_ES
dc.subject.meshCytochrome P-450 Enzyme Systemes_ES
dc.subject.meshDrug Resistance, Fungales_ES
dc.subject.meshFluconazolees_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMeningitis, Cryptococcales_ES
dc.subject.meshMicrobial Sensitivity Testses_ES
dc.subject.meshMolecular Sequence Dataes_ES
dc.subject.meshOxidoreductaseses_ES
dc.subject.meshPlasmidses_ES
dc.subject.meshPoint Mutationes_ES
dc.subject.meshRecurrencees_ES
dc.subject.meshSterol 14-Demethylasees_ES
dc.titleG484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolatees_ES
dc.typeresearch articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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