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Beta-blockers after invasively managed STEMI vs NSTEMI without reduced ejection fraction: a prespecified analysis from the REBOOT trial.

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dc.contributor.authorRaposeiras-Roubín, Sergio
dc.contributor.authorAnguita, Manuel
dc.contributor.authorLatini, Roberto
dc.contributor.authorDomínguez-Rodríguez, Alberto
dc.contributor.authorBarrabés, José A
dc.contributor.authorSánchez, Pedro L
dc.contributor.authorOttani, Filippo
dc.contributor.authorPocock, Stuart
dc.contributor.authorOwen, Ruth
dc.contributor.authorCristobo, Pablo
dc.contributor.authorGómez-Talavera, Sandra
dc.contributor.authorStaszewsky, Lidia
dc.contributor.authorEscalera, Noemí
dc.contributor.authorFernández-Vázquez, Felipe
dc.contributor.authorBianco, Matteo
dc.contributor.authorPrada-Delgado, Óscar
dc.contributor.authorPérez-García, Carlos Nicolás
dc.contributor.authorPelizzoni, Valentina
dc.contributor.authorNavarro, Felipe
dc.contributor.authorPérez-Rivera, José-Ángel
dc.contributor.authorMartín-Gorria, Gonzalo
dc.contributor.authorVetrano, Alfredo
dc.contributor.authorFuster, Valentín
dc.contributor.authorRosselló, Xavier
dc.contributor.authorIbáñez, Borja
dc.date.accessioned2026-04-27T10:54:49Z
dc.date.available2026-04-27T10:54:49Z
dc.date.issued2026-04-23
dc.description.abstractRecent trials have questioned the clinical benefit of beta-blockers in post-myocardial infarction (MI) patients with preserved left ventricular ejection fraction (LVEF). However, differences in pathophysiology and risk profile between MI with and without ST-segment elevation (STEMI and NSTEMI) may influence the effect of beta-blockers. In this prespecified subgroup analysis of the REBOOT trial, which randomized invasively managed MI patients with LVEF > 40% to beta-blockers or control, we evaluated differences in long-term effects of the intervention between STEMI (n = 4296) and NSTEMI (n = 4142). The primary endpoint was a composite of all-cause death, reinfarction, or heart failure hospitalization over a median follow-up of 3.7 years.
dc.description.peerreviewedSí
dc.description.tableofcontentsREBOOT-CNIC was an independent trial funded by the Centro Nacional de Investigaciones Cardiovasculares (CNIC). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by ICIU/AEI/10.13039/501100011033).
dc.identifier.citationRev Esp Cardiol (Engl Ed). 2026 Apr 23:S1885-5857(26)00076-9.
dc.identifier.journalREVISTA ESPAÑOLA DE CARDIOLOGIA
dc.identifier.pubmedID42034335
dc.identifier.urihttps://hdl.handle.net/20.500.12105/27446
dc.language.isoeng
dc.publisherEDICIONES DOYMA
dc.relation.isreferencedbyPubMed
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MICIU/AEI/10.13039/501100011033
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CEX2020-001041-S/MICIU/AEI/10.13039/501100011033
dc.relation.publisherversion10.1016/j.rec.2026.03.007
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAcute coronary syndrome
dc.subjectBeta-blockers
dc.subjectBloqueadores beta
dc.subjectEnsayo clínico aleatorizado
dc.subjectIAMCEST
dc.subjectIAMSEST
dc.subjectNSTEMI
dc.subjectRandomized controlled trial
dc.subjectSTEMI
dc.subjectSíndrome coronario agudo
dc.titleBeta-blockers after invasively managed STEMI vs NSTEMI without reduced ejection fraction: a prespecified analysis from the REBOOT trial.
dc.typeresearch article
dc.type.hasVersionP
dspace.entity.typePublication

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