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Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

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dc.contributor.authorZhou, Xiang
dc.contributor.authorHan, Seungbin
dc.contributor.authorCebulla, Nadine
dc.contributor.authorHaertle, Larissa
dc.contributor.authorSteinhardt, Maximilian J
dc.contributor.authorSchirmer, Daniel
dc.contributor.authorRunau, Eva
dc.contributor.authorFlamm, Leon
dc.contributor.authorTerhorst, Calvin
dc.contributor.authorJähnel, Laura
dc.contributor.authorVogt, Cornelia
dc.contributor.authorNerreter, Silvia
dc.contributor.authorTeufel, Eva
dc.contributor.authorStanojkovska, Emilia
dc.contributor.authorMersi, Julia
dc.contributor.authorMunawar, Umair
dc.contributor.authorSchindehütte, Magnus
dc.contributor.authorBlum, Robert
dc.contributor.authorReinhold, Ann-Kristin
dc.contributor.authorScherf-Clavel, Oliver
dc.contributor.authorRittner, Heike L
dc.contributor.authorPham, Mirko
dc.contributor.authorRasche, Leo
dc.contributor.authorEinsele, Hermann
dc.contributor.authorSommer, Claudia
dc.contributor.authorKortüm, K Martin
dc.contributor.funderGerman Research Foundation (DFG)es_ES
dc.contributor.funderInterdisciplinary Center for Clinical Research Wuerzburg (IZKF Wuerzburg)es_ES
dc.contributor.funderDeutsche Krebshilfees_ES
dc.date.accessioned2024-09-16T08:17:08Z
dc.date.available2024-09-16T08:17:08Z
dc.date.issued2023-05-16
dc.description.abstractWe analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were significantly enriched in patients with painful peripheral neuropathy (PNP) (P < 0.0001), and homozygous mutated rs2839629 genotype was significantly enriched in patients with pain compared to patients with no pain (P = 0.04). In summary, both SNPs rs2839629 and/or rs915854 may be potential biomarkers predicting an increased risk to develop painful PNP under bortezomib.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by the German Research Foundation (DFG) via the Clinical Research Unit KFO5001 "Resolve PAIN", the German Cancer Aid via the Mildred Scheel Early Career Center Wuerzburg (MSNZ Wuerzburg), and the Interdisciplinary Center for Clinical Research Wuerzburg (IZKF Wuerzburg)es_ES
dc.format.number1es_ES
dc.format.page52es_ES
dc.format.volume11es_ES
dc.identifier.citationBiomark Res . 2023 1;11(1):52es_ES
dc.identifier.doi10.1186/s40364-023-00490-9es_ES
dc.identifier.issn2050-7771es_ES
dc.identifier.journalBiomarker researches_ES
dc.identifier.pubmedID37194045es_ES
dc.identifier.urihttps://hdl.handle.net/20.500.12105/23113
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC)
dc.relation.publisherversionhttps://doi.org/10.1186/s40364-023-00490-9es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Unidades técnicas::Unidad de Investigación Clínica de Tumores Hematológicos H12O-CNIOes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleBortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1es_ES
dc.typeletter to the editores_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isPublisherOfPublication4fe896aa-347b-437b-a45b-95f4b60d9fd3
relation.isPublisherOfPublication.latestForDiscovery4fe896aa-347b-437b-a45b-95f4b60d9fd3

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