Publication:
The Many Ways to Deal with STING

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dc.contributor.authorCoderch, Claire
dc.contributor.authorArranz-Herrero, Javier
dc.contributor.authorNistal-Villan, Estanislao
dc.contributor.authorde Pascual-Teresa, Beatriz
dc.contributor.authorRius-Rocabert, Sergio
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)es_ES
dc.date.accessioned2023-06-06T12:08:18Z
dc.date.available2023-06-06T12:08:18Z
dc.date.issued2023-05-20
dc.description.abstractThe stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by Ministerio de Ciencia e Innovación PID2019-105761RBI00/AEI/10.13039/501100011033. J.A-H. was supported by the PFIS fellowship co-funded by the FEDER/FSE and the ISCIII.es_ES
dc.format.number10es_ES
dc.format.page9032es_ES
dc.format.volume24es_ES
dc.identifier.citationInt J Mol Sci. 2023 May 20;24(10):9032.es_ES
dc.identifier.doi10.3390/ijms24109032es_ES
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.identifier.pubmedID37240378es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16146
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PID2019-105761RBI00es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms24109032es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectIFNes_ES
dc.subjectSTINGes_ES
dc.subjectAntiviral responsees_ES
dc.subject.meshNucleotides, Cyclices_ES
dc.subject.meshAdjuvants, Immunologices_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBinding Siteses_ES
dc.titleThe Many Ways to Deal with STINGes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationd86c8339-2f04-45eb-8f87-0c1e0998aabf
relation.isAuthorOfPublication.latestForDiscoveryd86c8339-2f04-45eb-8f87-0c1e0998aabf
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