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The dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway

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dc.contributor.authorLefaki, Maria
dc.contributor.authorPapaevgeniou, Nikoletta
dc.contributor.authorTur, Josep A
dc.contributor.authorVorgias, Constantinos E
dc.contributor.authorSykiotis, Gerasimos P
dc.contributor.authorChondrogianni, Niki
dc.date.accessioned2024-09-13T09:11:54Z
dc.date.available2024-09-13T09:11:54Z
dc.date.issued2020-01
dc.description.abstract18 alpha-Glycyrrhetinic acid (18 alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context. Although various beneficial properties of 18 alpha-GA have been revealed, including its anti-oxidation and anti-aging activity, its possible protective effect against DNA damage has never been addressed. In this study, we investigated the potential beneficial properties of 18 alpha-GA against DNA damage induced by mitomycin C (MMC) treatment. Using human primary fibroblasts exposed to MMC following pre-treatment with 18 alpha-GA, we reveal an Nrf2-mediated protective effect against MMC-induced cell death that depends on extracellular signal-regulated kinase (ERK) signaling. In total, our results reveal an additional beneficial effect of the Nrf2 activator 18 alpha-GA, suggesting that this important phytochemical compound is a potential candidate in preventive and/or therapeutic schemes against conditions (such as aging) or diseases that are characterized by both oxidative stress and DNA damage.en
dc.description.sponsorshipWe would like to thank Ms M. Bekyrou for technical assistance with comet assay. This work was funded by two Research Funding Programs: Thales GenAge [QALHS AP:10479/3.7.12 MIS380228] (to N.C.) and MAESTRO (to N.C.) co-financed by the European Union and Greek national funds through the Operational Program Education and Lifelong Learning of the National Strategic Reference Framework (NSRF) and an Empirikion Foundation Scientific Project to N.C. Research from N.C. lab is currently co-financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE (project code: T1EDK-00353 and T1EDK-01610) as well by the project STHENOS-b'' (MIS 5002398), which is funded by the Operational Program Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020) and co-financed by Greece and the EU (European Regional Development Fund). N.P. receives a PhD fellowship from Empirikion Foundation. J.A.T. is funded by CIBEROBN (Physiopathology of Obesity and Nutrition) CB12/03/30038 (Instituto de Salud Carlos III, Spain and the European Regional Development Fund. G.P.S. is funded by the Swiss National Science Fund [IZCOZ0-177070 and 31003A_182105] and by a Leenaards Foundation 2016 Fellowship for Academic Promotion in Clinical Medicine. This research article/publication is based upon work from COST Action NutRedOx-CA16112 supported by COST (European Cooperation in Science and Technology) (to J.A.T., G.P.S. and N.C.).es_ES
dc.format.page101317es_ES
dc.format.volume28es_ES
dc.identifier.citationLefaki M, Papaevgeniou N, Tur JA, Vorgias CE, Sykiotis GP, Chondrogianni N. The dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway. Redox Biol. 2020 Jan;28:101317.en
dc.identifier.doi10.1016/j.redox.2019.101317
dc.identifier.issn2213-2317
dc.identifier.journalRedox Biologyes_ES
dc.identifier.otherhttps://hdl.handle.net/20.500.13003/19854
dc.identifier.pubmedID31505326es_ES
dc.identifier.puiL2002834091
dc.identifier.scopus2-s2.0-85071869131
dc.identifier.urihttps://hdl.handle.net/20.500.12105/22890
dc.identifier.wos501490700063
dc.language.isoengen
dc.publisherElsevier
dc.relation.publisherversionhttps://dx.doi.org/10.1016/j.redox.2019.101317en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject18 alpha-Glycyrrhetinic acid
dc.subjectNrf2
dc.subjectDNA damage
dc.subjectMitomycin C
dc.subjectERK pathway
dc.subjectPhytochemicals
dc.subject.decsRegulación de la Expresión Génica*
dc.subject.decsMitomicina*
dc.subject.decsDaño del ADN*
dc.subject.decsHumanos*
dc.subject.decsFibroblastos*
dc.subject.decsEspecies Reactivas de Oxígeno*
dc.subject.decsEstrés Oxidativo*
dc.subject.decsApoptosis*
dc.subject.decsÁcido Glicirretínico*
dc.subject.decsSistema de Señalización de MAP Quinasas*
dc.subject.decsFactor 2 Relacionado con NF-E2*
dc.subject.decsLínea Celular*
dc.subject.meshGlycyrrhetinic Acid*
dc.subject.meshOxidative Stress*
dc.subject.meshApoptosis*
dc.subject.meshMAP Kinase Signaling System*
dc.subject.meshReactive Oxygen Species*
dc.subject.meshFibroblasts*
dc.subject.meshGene Expression Regulation*
dc.subject.meshHumans*
dc.subject.meshNF-E2-Related Factor 2*
dc.subject.meshDNA Damage*
dc.subject.meshCell Line*
dc.subject.meshMitomycin*
dc.titleThe dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathwayen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublication7d471502-7bd5-4f7a-90a4-8274382509ef
relation.isPublisherOfPublication.latestForDiscovery7d471502-7bd5-4f7a-90a4-8274382509ef

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