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Cell transcriptomic atlas of the non-human primate Macaca fascicularis.

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dc.contributor.authorHan, Lei
dc.contributor.authorWei, Xiaoyu
dc.contributor.authorLiu, Chuanyu
dc.contributor.authorVolpe, Giacomo
dc.contributor.authorZhuang, Zhenkun
dc.contributor.authorZou, Xuanxuan
dc.contributor.authorWang, Zhifeng
dc.contributor.authorPan, Taotao
dc.contributor.authorYuan, Yue
dc.contributor.authorZhang, Xiao
dc.contributor.authorFan, Peng
dc.contributor.authorGuo, Pengcheng
dc.contributor.authorLai, Yiwei
dc.contributor.authorLei, Ying
dc.contributor.authorLiu, Xingyuan
dc.contributor.authorYu, Feng
dc.contributor.authorShangguan, Shuncheng
dc.contributor.authorLai, Guangyao
dc.contributor.authorDeng, Qiuting
dc.contributor.authorLiu, Ya
dc.contributor.authorWu, Liang
dc.contributor.authorShi, Quan
dc.contributor.authorYu, Hao
dc.contributor.authorHuang, Yunting
dc.contributor.authorCheng, Mengnan
dc.contributor.authorXu, Jiangshan
dc.contributor.authorLiu, Yang
dc.contributor.authorWang, Mingyue
dc.contributor.authorWang, Chunqing
dc.contributor.authorZhang, Yuanhang
dc.contributor.authorXie, Duo
dc.contributor.authorYang, Yunzhi
dc.contributor.authorYu, Yeya
dc.contributor.authorZheng, Huiwen
dc.contributor.authorWei, Yanrong
dc.contributor.authorHuang, Fubaoqian
dc.contributor.authorLei, Junjie
dc.contributor.authorHuang, Waidong
dc.contributor.authorZhu, Zhiyong
dc.contributor.authorLu, Haorong
dc.contributor.authorWang, Bo
dc.contributor.authorWei, Xiaofeng
dc.contributor.authorChen, Fengzhen
dc.contributor.authorYang, Tao
dc.contributor.authorDu, Wensi
dc.contributor.authorChen, Jing
dc.contributor.authorXu, Shibo
dc.contributor.authorAn, Juan
dc.contributor.authorWard, Carl
dc.contributor.authorWang, Zongren
dc.contributor.authorPei, Zhong
dc.contributor.authorWong, Chi-Wai
dc.contributor.authorLiu, Xiaolei
dc.contributor.authorZhang, Huafeng
dc.contributor.authorLiu, Mingyuan
dc.contributor.authorQin, Baoming
dc.contributor.authorSchambach, Axel
dc.contributor.authorIsern, Joan
dc.contributor.authorFeng, Liqiang
dc.contributor.authorLiu, Yan
dc.contributor.authorGuo, Xiangyu
dc.contributor.authorLiu, Zhen
dc.contributor.authorSun, Qiang
dc.contributor.authorMaxwell, Patrick H
dc.contributor.authorBarker, Nick
dc.contributor.authorMuñoz-Cánoves, Pura
dc.contributor.authorGu, Ying
dc.contributor.authorMulder, Jan
dc.contributor.authorUhlen, Mathias
dc.contributor.authorTan, Tao
dc.contributor.authorLiu, Shiping
dc.contributor.authorYang, Huanming
dc.contributor.authorWang, Jian
dc.contributor.authorHou, Yong
dc.contributor.authorXu, Xun
dc.contributor.authorEsteban, Miguel A
dc.contributor.authorLiu, Longqi
dc.date.accessioned2023-03-27T11:13:12Z
dc.date.available2023-03-27T11:13:12Z
dc.date.issued2022-04
dc.description.abstractStudying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipWe thank W. Liu and L. Xu from the Huazhen Laboratory Animal Breeding Centre for helping in the collection of monkey tissues, D. Zhu and H. Li from the Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) for technical help, G. Guo and H. Sun from Zhejiang University for providing HCL and MCA gene expression data matrices, G. Dong and C. Liu from BGI Research, and X. Zhang, P. Li and C. Qi from the Guangzhou Institutes of Biomedicine and Health for experimental advice or providing reagents. This work was supported by the Shenzhen Basic Research Project for Excellent Young Scholars (RCYX20200714114644191), Shenzhen Key Laboratory of Single-Cell Omics (ZDSYS20190902093613831), Shenzhen Bay Laboratory (SZBL2019062801012) and Guangdong Provincial Key Laboratory of Genome Read and Write (2017B030301011). In addition, L.L. was supported by the National Natural Science Foundation of China (31900466), Y. Hou was supported by the Natural Science Foundation of Guangdong Province (2018A030313379) and M.A.E. was supported by a Changbai Mountain Scholar award (419020201252), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030502), a Chinese Academy of Sciences–Japan Society for the Promotion of Science joint research project (GJHZ2093), the National Natural Science Foundation of China (92068106, U20A2015) and the Guangdong Basic and Applied Basic Research Foundation (2021B1515120075). M.L. was supported by the National Key Research and Development Program of China (2021YFC2600200).es_ES
dc.format.number7907es_ES
dc.format.page723es_ES
dc.format.volume604es_ES
dc.identifier.citationNature. 2022 Apr;604(7907):723-731es_ES
dc.identifier.doi10.1038/s41586-022-04587-3es_ES
dc.identifier.e-issn1476-4687es_ES
dc.identifier.journalNaturees_ES
dc.identifier.pubmedID35418686es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15715
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.publisherversion10.1038/s41586-022-04587-3es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio de Regeneración Tisulares_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshMacaca fascicularises_ES
dc.subject.meshTranscriptomees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCell Communicationes_ES
dc.subject.meshReceptors, Viruses_ES
dc.subject.meshWnt Signaling Pathwayes_ES
dc.titleCell transcriptomic atlas of the non-human primate Macaca fascicularis.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationafcc6b05-98dc-43c0-846a-0bb8428a6b74
relation.isAuthorOfPublication.latestForDiscoveryafcc6b05-98dc-43c0-846a-0bb8428a6b74

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