Publication:
Levofloxacin treatment failure in Haemophilus influenzae pneumonia.

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Centers for Disease Control and Prevention (CDC)
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We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV genes.

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Emerg Infect Dis . 2003 Nov;9(11):1475-8.

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