Publication:
The Evolving Landscape of Brain Metastasis.

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dc.contributor.authorValiente, Manuel
dc.contributor.authorAhluwalia, Manmeet S
dc.contributor.authorBoire, Adrienne
dc.contributor.authorBrastianos, Priscilla K
dc.contributor.authorGoldberg, Sarah B
dc.contributor.authorLee, Eudocia Q
dc.contributor.authorLe Rhun, Emilie
dc.contributor.authorPreusser, Matthias
dc.contributor.authorWinkler, Frank
dc.contributor.authorSoffietti, Riccardo
dc.contributor.funderUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI)
dc.contributor.funderMinisterio de Ciencia (España)
dc.contributor.funderBristol-Myers Squibb Melanoma Research Alliance Young Investigator Award
dc.contributor.funderBeug Foundation Prize for Metastasis Research
dc.contributor.funderGerman Cancer Aid (Deutsche Krebshilfe)
dc.date.accessioned2024-12-10T10:14:46Z
dc.date.available2024-12-10T10:14:46Z
dc.date.issued2018-03
dc.descriptionWe thank members of our laboratories for helpful discussions. We are grateful for funding from the National Cancer Institute 2P30CA008748-48, to A.B.), Mundipharma (E.L.R.), Amgen (E.L.R.), German Cancer Aid (Deutsche Krebshilfe), Translational Oncology Program, the Prevent Brain Metastasis Consortium (F.W.), MINECO-Retos (SAF2014-57243-R, to M.V.), MINECO-Europa Excelencia (SAF2015-62547-ERC, to M.V.), IX FERO Grant for Research in Oncology (M.V.), Bristol-Myers Squibb Melanoma Research Alliance Young Investigator Award 2017 (M.V.), and the Beug Foundation Prize for Metastasis Research 2017 (M.V.). M.V. is a Ramon y Cajal Investigator (RYC-2013-13365).
dc.description.abstractMetastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.
dc.description.peerreviewedSí
dc.format.number3
dc.format.page176-196
dc.format.volume4
dc.identifier.citationTrends Cancer . 2018 Mar;4(3):176-196
dc.identifier.journalTrends in Cancer
dc.identifier.pmchttps://pmc.ncbi.nlm.nih.gov/articles/PMC6602095/pdf/nihms-1037277.pdf
dc.identifier.pubmedID29506669
dc.identifier.urihttps://hdl.handle.net/20.500.12105/25875
dc.language.isoeng
dc.publisherCell Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2014-57243-R/ES/ANALISIS DEL PAPEL DE LOS ASTROCITOS REACTIVOS EN LA METASTASIS CEREBRAL/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-62547-ERC/ES/DECONSTRUYENDO LA ENFERMEDAD METASTATICA EN EL CEREBRO/
dc.relation.publisherversionhttp://doi.org.10.1016/j.trecan.2018.01.003
dc.repisalud.institucionCNIO
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Metástasis Cerebral
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectbrain metastasis
dc.subjectgenomics
dc.subjectmicroenvironment
dc.subjectneurocognition
dc.subjectprevention
dc.subjecttherapy
dc.titleThe Evolving Landscape of Brain Metastasis.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication9ff41ae3-2484-4d1c-bfb4-9f7a64487317
relation.isAuthorOfPublication.latestForDiscovery9ff41ae3-2484-4d1c-bfb4-9f7a64487317

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