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Differential iNKT and T Cells Activation in Non-Alcoholic Fatty Liver Disease and Drug-Induced Liver Injury.

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dc.contributor.authorCaballano-Infantes, Estefanía
dc.contributor.authorGarcía-García, Alberto
dc.contributor.authorLopez-Gomez, Carlos
dc.contributor.authorCueto, Alejandro
dc.contributor.authorRobles-Diaz, Mercedes
dc.contributor.authorOrtega-Alonso, Aida
dc.contributor.authorMartín-Reyes, Flores
dc.contributor.authorAlvarez-Alvarez, Ismael
dc.contributor.authorArranz-Salas, Isabel
dc.contributor.authorRuiz-Cabello, Francisco
dc.contributor.authorLucena, Isabel M
dc.contributor.authorGarcía-Fuentes, Eduardo
dc.contributor.authorAndrade, Raúl J
dc.contributor.authorGarcía-Cortes, Miren
dc.date.accessioned2024-02-19T15:32:35Z
dc.date.available2024-02-19T15:32:35Z
dc.date.issued2021-12-28
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) and idiosyncratic drug-induced liver injury (DILI) could share molecular mechanisms involving the immune system. We aimed to identify activation immunological biomarkers in invariant natural killer T (iNKT) and CD4/CD8+ T cells in NAFLD and DILI. We analyzed the activation profile (CD69, CD25, and HLA-DR) and natural killer group 2 member D (NKG2D) on iNKT cells, and CD4/CD8 T cells in peripheral blood mononuclear cells from NAFLD, with or without significant liver fibrosis, and DILI patients. There was an increase in iNKT cells in NAFLD patients compared to DILI or control subjects. Regarding the cellular activation profile, NAFLD with significant liver fibrosis (F ≥ 2) displayed higher levels of CD69+iNKT cells compared to NAFLD with none or mild liver fibrosis (F ≤ 1) and control patients. CD69+iNKT positively correlated with insulin resistance, aspartate aminotransferase (AST) level, liver fibrosis-4 index (FIB4) and AST to Platelet Ratio Index (APRI). DILI patients showed an increase in CD69+ and HLA-DR+ in both CD4+ and CD8+ T cells, detecting the most relevant difference in the case of CD69+CD8+ T cells. CD69+iNKT may be a biomarker to assess liver fibrosis progression in NAFLD. CD69+CD8+ T cells were identified as a potential distinctive biomarker for distinguishing DILI from NAFLD.
dc.format.number1es_ES
dc.format.volume10es_ES
dc.identifier.doi10.3390/biomedicines10010055
dc.identifier.issn2227-9059
dc.identifier.journalBiomedicineses_ES
dc.identifier.otherhttp://hdl.handle.net/10668/20811
dc.identifier.pubmedID35052736es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18527
dc.language.isoeng
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdrug-induced liver injury (DILI)
dc.subjectimmune response
dc.subjectimmunophenotype
dc.subjectliver fibrosis
dc.subjectnon-alcoholic fatty liver disease (NAFLD)
dc.titleDifferential iNKT and T Cells Activation in Non-Alcoholic Fatty Liver Disease and Drug-Induced Liver Injury.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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