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Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

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dc.contributor.authorBenschop, Kimberley SM
dc.contributor.authorBroberg, Eeva K
dc.contributor.authorHodcroft, Emma
dc.contributor.authorSchmitz, Dennis
dc.contributor.authorAlbert, Jan
dc.contributor.authorBaicus, Anda
dc.contributor.authorBailly, Jean-Luc
dc.contributor.authorBaldvinsdottir, Gudrun
dc.contributor.authorBerginc, Natasa
dc.contributor.authorBlomqvist, Soile
dc.contributor.authorBöttcher, Sindy
dc.contributor.authorBrytting, Mia
dc.contributor.authorBujaki, Erika
dc.contributor.authorCabrerizo, Maria
dc.contributor.authorCelma, Cristina
dc.contributor.authorCinek, Ondrej
dc.contributor.authorClaas, Eric C J
dc.contributor.authorCremer, Jeroen
dc.contributor.authorDean, Jonathan
dc.contributor.authorDembinski, Jennifer L
dc.contributor.authorDemchyshyna, Iryna
dc.contributor.authorDiedrich, Sabine
dc.contributor.authorDudman, Susanne
dc.contributor.authorDunning, Jake
dc.contributor.authorDyrdak, Robert
dc.contributor.authorEmmanouil, Mary
dc.contributor.authorFarkas, Agnes
dc.contributor.authorDe Gascun, Cillian
dc.contributor.authorFournier, Guillaume
dc.contributor.authorGeorgieva, Irina
dc.contributor.authorGonzalez-Sanz, Ruben
dc.contributor.authorvan Hooydonk-Elving, Jolanda
dc.contributor.authorJääskeläinen, Anne J
dc.contributor.authorJancauskaite, Ruta
dc.contributor.authorKeeren, Kathrin
dc.contributor.authorFischer, Thea K
dc.contributor.authorKrokstad, Sidsel
dc.contributor.authorNikolaeva-Glomb, Lubomira
dc.contributor.authorNovakova, Ludmila
dc.contributor.authorMidgley, Sofie Elisabeth
dc.contributor.authorMirand, Audrey
dc.contributor.authorMolenkamp, Richard
dc.contributor.authorMorley, Ursula
dc.contributor.authorMossong, Joël
dc.contributor.authorMuralyte, Svajune
dc.contributor.authorMurk, Jean-Luc
dc.contributor.authorNguyen, Trung
dc.contributor.authorNordbø, Svein A
dc.contributor.authorÖsterback, Riikka
dc.contributor.authorPas, Suzan
dc.contributor.authorPellegrinelli, Laura
dc.contributor.authorPogka, Vassiliki
dc.contributor.authorProchazka, Birgit
dc.contributor.authorRainetova, Petra
dc.contributor.authorVan Ranst, Marc
dc.contributor.authorRoorda, Lieuwe
dc.contributor.authorSchuffenecker, Isabelle
dc.contributor.authorSchuurman, Rob
dc.contributor.authorStoyanova, Asya
dc.contributor.authorTempleton, Kate
dc.contributor.authorVerweij, Jaco J
dc.contributor.authorVoulgari-Kokota, Androniki
dc.contributor.authorVuorinen, Tytti
dc.contributor.authorWollants, Elke
dc.contributor.authorWolthers, Katja C
dc.contributor.authorZakikhany, Katherina
dc.contributor.authorNeher, Richard
dc.contributor.authorHarvala, Heli
dc.contributor.authorSimmonds, Peter
dc.contributor.funderMinistry of Health Welfare and Sport (Países Bajos)
dc.contributor.funderUnión Europea. Comisión Europea. H2020
dc.contributor.funderAristotle University of Thessaloniki (Grecia)es_ES
dc.contributor.funderWellcome Trust
dc.contributor.funderNational Institute for Health and Disability Insurance (Bélgica)es_ES
dc.date.accessioned2022-07-20T11:54:42Z
dc.date.available2022-07-20T11:54:42Z
dc.date.issued2021-06
dc.description.abstractIn 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThe study was supported by the Ministry of Health, Welfare and Sport, the Netherlands as part of the EV surveillance program of the National Institute for Public Health and the Environment; the European Union Horizon 2020 research and innovation program (COMPARE grant no. 643476 from Aristotle University of Thessaloniki, Greece); the Wellcome Trust (grant no. ISSF204826/Z/16/Z); the Belgian National Reference Center for Enteroviruses from the RIZIV/INAMI (National Institute for Health and Disability Insurance); and the HONOURs Horizon 2020 Marie Sklodowska-Curie Training Network (grant no. 721367).es_ES
dc.format.number6es_ES
dc.format.page1616-1626es_ES
dc.format.volume27es_ES
dc.identifier.citationEmerg Infect Dis. 2021 Jun;27(6):1616-1626.es_ES
dc.identifier.doi10.3201/eid2706.203096es_ES
dc.identifier.e-issn1080-6059es_ES
dc.identifier.journalEmerging Infectious Diseaseses_ES
dc.identifier.pubmedID34013874es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14756
dc.language.isoenges_ES
dc.publisherCenters for Disease Control and Prevention (CDC)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/643476/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/721367/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.3201/eid2706.203096es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectEuropees_ES
dc.subjectEuropean Non-Polio Enterovirus Networkes_ES
dc.subjectMolecular epidemiologyes_ES
dc.subjectNextstrain; echovirus 30es_ES
dc.subjectEnteroviruses_ES
dc.subjectEpidemiological monitoringes_ES
dc.subjectEvolutionary trajectoryes_ES
dc.subjectGenetic recombinationes_ES
dc.subjectMeningitis/encephalitises_ES
dc.subjectNeurological manifestationses_ES
dc.subjectViruseses_ES
dc.subjectWhole-genome sequencinges_ES
dc.subject.meshEchovirus Infectionses_ES
dc.subject.meshEnterovirus Infectionses_ES
dc.subject.meshEnterovirus B, Humanes_ES
dc.subject.meshEuropees_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMolecular Epidemiologyes_ES
dc.subject.meshPhylogenyes_ES
dc.subject.meshSequence Analysis, DNAes_ES
dc.titleMolecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europees_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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