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Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects

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dc.contributor.authorCastillo, Pedro
dc.contributor.authorPalou, Mariona
dc.contributor.authorYau-Qiu, Zhi Xin
dc.contributor.authorRodriguez, Ana M
dc.contributor.authorPalou, Andreu
dc.contributor.authorPicó, Catalina
dc.date.accessioned2024-09-18T06:43:47Z
dc.date.available2024-09-18T06:43:47Z
dc.date.issued2021-09
dc.description.abstractWe studied whether myo-inositol supplementation throughout lactation, alone and combined with leptin, may reverse detrimental effects on hypothalamic structure and function caused by gestational calorie gestation (CR) in rats. Candidate early transcript-based biomarkers of metabolic health in peripheral blood mononuclear cells (PBMC) were also studied. offspring of dams exposed to 25% gestational CR and supplemented during lactation with physiological doses of leptin (CR-L), myo-inositol (CR-M), the combination (CR-LM), or the vehicle (CR-V) as well as control rats (CON-V) were followed and sacrificed at postnatal day 25. Myo-inositol and the combination increased the number of neurons in arcuate nucleus (ARC) (only in females) and paraventricular nucleus, and myo-inositol (alone) restored the number of alpha MSH+ neurons in ARC. Hypothalamic mRNA levels of Lepr in CR-M and Insr in CR-M and CR-LM males were higher than in CR-V and CON-V, respectively. In PBMC, increased expression levels of Lrp11 and Gls in CR-V were partially normalized in all supplemented groups (but only in males for Gls). Therefore, myo-inositol supplementation throughout lactation, alone and combined with leptin, reverts programmed alterations by fetal undernutrition on hypothalamic structure and gene expression of potential early biomarkers of metabolic health in PBMC, which might be attributed, in part, to increased leptin sensitivity.en
dc.description.sponsorshipThis research was supported by the Spanish Government (PGC2018-097436-B-I00 (MCIU/AEI/FEDER, UE)) and the Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion, CIBERobn. P.C. and Z.X.Y.-Q. were granted a PhD fellowship funded by the Spanish Government.es_ES
dc.format.number9es_ES
dc.format.page3257es_ES
dc.format.volume13es_ES
dc.identifier.citationCastillo P, Palou M, Yau-Qiu ZX, Rodriguez AM, Palou A, Pico C. Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects. Nutrients. 2021 Sep;13(9):3257.en
dc.identifier.doi10.3390/nu13093257
dc.identifier.e-issn2072-6643es_ES
dc.identifier.journalNutrientses_ES
dc.identifier.otherhttps://hdl.handle.net/20.500.13003/19701
dc.identifier.pubmedID34579137es_ES
dc.identifier.puiL2013790157
dc.identifier.scopus2-s2.0-85115117498
dc.identifier.urihttps://hdl.handle.net/20.500.12105/23283
dc.identifier.wos700147600001
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://dx.doi.org/10.3390/nu13093257en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFetal undernutrition
dc.subjectMyo-inositol
dc.subjectLeptin
dc.subjectLactation period
dc.subjectMetabolic programming
dc.subjectArcuate nucleus
dc.subjectParaventricular nucleus
dc.subjectPBMC
dc.subject.decsAnimales*
dc.subject.decsRatas Wistar*
dc.subject.decsFemenino*
dc.subject.decsInositol*
dc.subject.decsHipotálamo*
dc.subject.decsMasculino*
dc.subject.decsRestricción Calórica*
dc.subject.decsReceptores de Leptina*
dc.subject.decsLactancia*
dc.subject.decsRatas*
dc.subject.decsLeucocitos Mononucleares*
dc.subject.decsEmbarazo*
dc.subject.decsAnimales Lactantes*
dc.subject.decsSuplementos Dietéticos*
dc.subject.decsLeptina*
dc.subject.decsEfectos Tardíos de la Exposición Prenatal*
dc.subject.meshAnimals, Suckling*
dc.subject.meshLeukocytes, Mononuclear*
dc.subject.meshLactation*
dc.subject.meshPregnancy*
dc.subject.meshMale*
dc.subject.meshInositol*
dc.subject.meshRats, Wistar*
dc.subject.meshHypothalamus*
dc.subject.meshLeptin*
dc.subject.meshFemale*
dc.subject.meshRats*
dc.subject.meshAnimals*
dc.subject.meshCaloric Restriction*
dc.subject.meshReceptors, Leptin*
dc.subject.meshDietary Supplements*
dc.subject.meshPrenatal Exposure Delayed Effects*
dc.titleMyo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effectsen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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