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Early prognostic value of an Algorithm based on spectral Variables of Ventricular fibrillAtion from the EKG of patients with suddEn cardiac death: A multicentre observational study (AWAKE)

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dc.contributor.authorPalacios-Rubio, Julián
dc.contributor.authorMarina-Breysse, Manuel
dc.contributor.authorQuintanilla, Jorge G.
dc.contributor.authorGil-Perdomo, José Miguel
dc.contributor.authorJuárez-Fernández, Miriam
dc.contributor.authorGarcia-Gonzalez, Inés
dc.contributor.authorRial-Bastón, Verónica
dc.contributor.authorCorcobado, María Carmen
dc.contributor.authorEspinosa, María Carmen
dc.contributor.authorRuiz, Francisco
dc.contributor.authorGómez-Mascaraque Pérez, Francisco
dc.contributor.authorBringas-Bollada, María
dc.contributor.authorLillo-Castellano, Jose Maria
dc.contributor.authorPérez-Castellano, Nicasio
dc.contributor.authorMartínez-Sellés, Manuel
dc.contributor.authorLópez de Sá, Esteban
dc.contributor.authorMartín-Benítez, Juan Carlos
dc.contributor.authorPérez-Villacastín, Julián
dc.contributor.authorFilgueiras-Rama, David
dc.contributor.funderSociedad Española de Cardiología
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)
dc.contributor.funderFundación ProCNIC
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.date.accessioned2019-02-11T10:04:58Z
dc.date.available2019-02-11T10:04:58Z
dc.date.issued2018-12
dc.description.abstractOBJECTIVE: Ventricular fibrillation (VF)-related sudden cardiac death (SCD) is a leading cause of mortality and morbidity. Current biological and imaging parameters show significant limitations on predicting cerebral performance at hospital admission. The AWAKE study (NCT03248557) is a multicentre observational study to validate a model based on spectral ECG analysis to early predict cerebral performance and survival in resuscitated comatose survivors. METHODS: Data from VF ECG tracings of patients resuscitated from SCD will be collected using an electronic Case Report Form. Patients can be either comatose (Glasgow Coma Scale - GCS - ≤8) survivors undergoing temperature control after return of spontaneous circulation (RoSC), or those who regain consciousness (GCS=15) after RoSC; all admitted to Intensive Cardiac Care Units in 4 major university hospitals. VF tracings prior to the first direct current shock will be digitized and analyzed to derive spectral data and feed a predictive model to estimate favorable neurological performance (FNP). The results of the model will be compared to the actual prognosis. RESULTS: The primary clinical outcome is FNP during hospitalization. Patients will be categorized into 4 subsets of neurological prognosis according to the risk score obtained from the predictive model. The secondary clinical outcomes are survival to hospital discharge, and FNP and survival after 6 months of follow-up. The model-derived categorisation will be also compared with clinical variables to assess model sensitivity, specificity, and accuracy. CONCLUSIONS: A model based on spectral analysis of VF tracings is a promising tool to obtain early prognostic data after SCD.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipDr. Palacios-Rubio has been awarded with a fellowship grant from the Spanish Society of Cardiology related to the execution of the featured study. The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Partially supported by European Regional Development Fund (ERDF). We thank the computing department of CNIC for their assistance during eCRF development.es_ES
dc.format.number5es_ES
dc.format.page460-467es_ES
dc.format.volume88es_ES
dc.identifier.citationArch Cardiol Mex. 2018; 88(5):460-467es_ES
dc.identifier.doi10.1016/j.acmx.2018.05.003es_ES
dc.identifier.e-issn1665-1731es_ES
dc.identifier.issn1405-9940es_ES
dc.identifier.journalArchivos de cardiologia de Mexicoes_ES
dc.identifier.pubmedID29885765es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7156
dc.language.isoenges_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.acmx.2018.05.003es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Desarrollo Avanzado sobre Mecanismos y Terapias de las Arritmiases_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnálisis de ondaes_ES
dc.subjectComaes_ES
dc.subjectEspañaes_ES
dc.subjectFibrilación ventriculares_ES
dc.subjectMuerte súbitaes_ES
dc.subjectPrognosises_ES
dc.subjectPronósticoes_ES
dc.subjectReanimaciónes_ES
dc.subjectResuscitationes_ES
dc.subjectSpaines_ES
dc.subjectSudden cardiac deathes_ES
dc.subjectVentricular fibrillationes_ES
dc.subjectWavelet analysises_ES
dc.titleEarly prognostic value of an Algorithm based on spectral Variables of Ventricular fibrillAtion from the EKG of patients with suddEn cardiac death: A multicentre observational study (AWAKE)es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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