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B Lymphocyte commitment program is driven by the proto-oncogene c-Myc.

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dc.contributor.authorVallespinós, Mireia
dc.contributor.authorFernández, David
dc.contributor.authorRodríguez, Lorena
dc.contributor.authorAlvaro-Blanco, Josué
dc.contributor.authorBaena, Esther
dc.contributor.authorOrtiz, Maitane
dc.contributor.authorDukovska, Daniela
dc.contributor.authorMartinez Garcia, Maria Dolores
dc.contributor.authorRojas, Ana
dc.contributor.authorMoreno de Alborán, Ignacio
dc.contributor.authorCampanero, Miguel R
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderFundación Mutua Madrileña
dc.contributor.funderFundación La Caixa
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderUnión Europea. Fondo Social Europeo (ESF/FSE)
dc.date.accessioned2024-02-01T12:40:55Z
dc.date.available2024-02-01T12:40:55Z
dc.date.issued2011-06-15
dc.descriptionWe thank I. Antón, C. Cobaleda, D. Martinez, and L. Torroja for a critical reading of the manuscript, M.A.R. Marcos for his input, M. Busslinger for ikneo mice, M. Reth for mb1-cre mice, H. Singh for EBF-MIG vectors, the Centro Nacional de Biotecnología animal facility and the Departamento de Inmunología y Oncología and Centro Nacional de Investigaciones Oncológicas FACS facility for help, and C. Mark for editorial assistance. Biotin–anti-NK1.1 Ab was a gift from C. Ardavín. This article is dedicated to the memory of M.A.R. Marcos.es_ES
dc.description.abstractc-Myc, a member of the Myc family of transcription factors, is involved in numerous biological functions including the regulation of cell proliferation, differentiation, and apoptosis in various cell types. Of all of its functions, the role of c-Myc in cell differentiation is one of the least understood. We addressed the role of c-Myc in B lymphocyte differentiation. We found that c-Myc is essential from early stages of B lymphocyte differentiation in vivo and regulates this process by providing B cell identity via direct transcriptional regulation of the ebf-1 gene. Our data show that c-Myc influences early B lymphocyte differentiation by promoting activation of B cell identity genes, thus linking this transcription factor to the EBF-1/Pax-5 pathway.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by grants (to I.M.A.) from the Spanish Ministry of Science and Innovation (SAF2008-00118), the Mutua Madrileña Foundation, the Concern Foundation, and the Madrid regional government (S-SAL-0304-2006). M.V. is the recipient of a fellowship from the Tecnoambiente Company, D.F. and E.B. are the recipients of fellowships from the Spanish Ministry of Science and Innovation, M.O. is supported by a fellowship from the Madrid regional government and Fondo Social Europeo, and D.D. is the recipient of a “La Caixa” Foundation fellowship.es_ES
dc.format.number12es_ES
dc.format.page6726es_ES
dc.format.volume186es_ES
dc.identifier.citationJ Immunol . 2011;186(12):6726-36es_ES
dc.identifier.doi10.4049/jimmunol.1002753es_ES
dc.identifier.e-issn1550-6606es_ES
dc.identifier.journalJournal of immunology (Baltimore, Md. : 1950)es_ES
dc.identifier.pubmedID21572027es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17413
dc.language.isoenges_ES
dc.publisherAmerican Association of Immunologists (AAI)
dc.relation.projectFISSAF2008-00118es_ES
dc.relation.publisherversionhttps://doi.org/10.4049/jimmunol.1002753.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Unidades técnicas::Unidad de Citometría de Flujoes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAnimalses_ES
dc.subject.meshB-Lymphocyteses_ES
dc.subject.meshCell Differentiationes_ES
dc.subject.meshGene Expression Regulationes_ES
dc.subject.meshMicees_ES
dc.subject.meshPAX5 Transcription Factores_ES
dc.subject.meshProto-Oncogene Mases_ES
dc.subject.meshProto-Oncogene Proteins c-myces_ES
dc.subject.meshSignal Transductiones_ES
dc.subject.meshTrans-Activatorses_ES
dc.subject.meshTranscription Factorses_ES
dc.subject.meshTranscription, Genetices_ES
dc.titleB Lymphocyte commitment program is driven by the proto-oncogene c-Myc.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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