Publication:
Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

Simple item page
dc.contributor.authorGerussi, Alessio
dc.contributor.authorNatalini, Ambra
dc.contributor.authorAntonangeli, Fabrizio
dc.contributor.authorMancuso, Clara
dc.contributor.authorAgostinetto, Elisa
dc.contributor.authorBarisani, Donatella
dc.contributor.authorDi Rosa, Francesca
dc.contributor.authorAndrade, Raul
dc.contributor.authorInvernizzi, Pietro
dc.contributor.authoraffiliation[Gerussi,A; Mancuso,C; Barisani,D; Invernizzi,P] Centre for Autoimmune Liver Diseases, Division of Gastroenterology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. [Gerussi,A; Mancuso,C; Barisani,D; Invernizzi,P] European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy. [Natalini,A; Antonangeli,F; Di Rosa,F] Institute of Molecular Biology and Pathology (IBPM), National Research Council of Italy (CNR), Rome, Italy. [Agostinetto,E] Academic Trials Promoting Team, Institut Jules Bordet, L’Universite’ Libre de Bruxelles (ULB), Brussels, Belgium. [Agostinetto,E] Medical Oncology and Hematology Unit, Humanitas Clinical and Research Center—IRCCS, Humanitas Cancer Center, Rozzano, Milan, Italy. [Agostinetto,E] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. [Andrade,R] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), UGC Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.
dc.date.accessioned2024-02-19T15:28:00Z
dc.date.available2024-02-19T15:28:00Z
dc.date.issued2021-04-27
dc.description.abstractDrug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.
dc.description.sponsorshipWe acknowledge that this research was partially supported by the Italian Ministry of University and Research (MIUR)—Department of Excellence project PREMIA (PREcision MedIcine Approach: bringing biomarker research to clinic). Research in FD’s lab was funded by MIUR project: 2017K55HLC_006.
dc.identifier.doi10.3390/ijms22094557
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational Journal of Molecular Scienceses_ES
dc.identifier.otherhttp://hdl.handle.net/10668/3615
dc.identifier.pubmedID33925355es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18324
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/9/4557/htmes
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInflammation
dc.subjectAutoimmune hepatitis
dc.subjectAutoimmunity
dc.subjectGenetics
dc.subjectDrug-induced liver injury
dc.subjectInflammation
dc.subjectHepatitis autoinmune
dc.subjectAutoimmunity
dc.subjectGenética
dc.subjectEnfermedad hepática inducida por sustancias y drogas
dc.subjectInflamación
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHepatitis, Autoimmune
dc.subject.meshHumans
dc.subject.meshImmunogenetics
dc.subject.meshModels, Theoretical
dc.subject.meshPhenotype
dc.subject.meshRisk Factors
dc.titleImmune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

Files

Collections

IBIMA-Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (Andalucía)