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A mouse model to identify cooperating signaling pathways in cancer.

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dc.contributor.authorMusteanu, Mónica
dc.contributor.authorBlaas, Leander
dc.contributor.authorZenz, Rainer
dc.contributor.authorSvinka, Jasmin
dc.contributor.authorHoffmann, Thomas
dc.contributor.authorGrabner, Beatrice
dc.contributor.authorSchramek, Daniel
dc.contributor.authorKantner, Hans-Peter
dc.contributor.authorMüller, Mathias
dc.contributor.authorKolbe, Thomas
dc.contributor.authorRülicke, Thomas
dc.contributor.authorMoriggl, Richard
dc.contributor.authorKenner, Lukas
dc.contributor.authorStoiber, Dagmar
dc.contributor.authorPenninger, Josef Martin
dc.contributor.authorPopper, Helmut
dc.contributor.authorCasanova, Emilio
dc.contributor.authorEferl, Robert
dc.contributor.funderEuropean Research Council (ERC)
dc.contributor.funderInstitute of Molecular Biotechnology (IMBA)
dc.contributor.funderAustrian Science Fund (FWF)
dc.contributor.funderLudwig Boltzmann Gesellschaft (LBG)
dc.date.accessioned2025-07-01T12:31:14Z
dc.date.available2025-07-01T12:31:14Z
dc.date.issued2012-09
dc.descriptionWe thank J. Downward (London Research Institute) for Ras effector mutants, A. Berns (Netherlands Cancer Institute) for Rosa26CreERT2 mice and G. Felsenfeld (National Institute of Diabetes and Digestive and Kidney Diseases, USA) for chicken 2xHS4 insulator sequences. We thank M. Sibilia and E. F. Wagner for critical reading of the manuscript and M. Mair and D. Khan for technical assistance. This work was supported by the Ludwig Boltzmann Gesellschaft (LBG), the Austrian Science Fund (FWF) grant SFB F28 to M. Muller, R. M. and R. E., the FWF Doktoratskolleg-plus grant 'Inflammation and Immunity' to M. Muller and R. E., the CCC Vienna Research grant to E. C. and R. E. and the Austrian Federal Ministry of Science and Research GENAU grant 'Austromouse' to M. Muller, T. R., J. M. P., E. C. and R. E. J. M. P. is supported by the Institute of Molecular Biotechnology (IMBA) and an advanced European Research Council (ERC) grant.
dc.description.abstractWe here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
dc.description.peerreviewedSí
dc.format.number9
dc.format.page897-900
dc.format.volume9
dc.identifier.citationNat Methods . 2012 Sep;9(9):897-900.
dc.identifier.pubmedID22863881
dc.identifier.urihttps://hdl.handle.net/20.500.12105/26794
dc.language.isoeng
dc.publisherSpringuer Nature
dc.relation.publisherversionhttps://doi: 10.1038/nmeth.2130.
dc.repisalud.institucionCNIO
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Oncología Experimental
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectoncogenic RAS
dc.subjectCELL
dc.subjectRECOMBINATION
dc.subjectACTIVATION
dc.titleA mouse model to identify cooperating signaling pathways in cancer.
dc.typeresearch article
dc.type.hasVersionEVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationaff72b01-c3b6-455f-b4d5-abd12819cadb
relation.isAuthorOfPublication.latestForDiscoveryaff72b01-c3b6-455f-b4d5-abd12819cadb

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