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Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response

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dc.contributor.authorZhang, Nan
dc.contributor.authorSchröppel, Bernd
dc.contributor.authorLal, Girdhari
dc.contributor.authorJakubzick, Claudia
dc.contributor.authorMao, Xia
dc.contributor.authorChen, Dan
dc.contributor.authorYin, Na
dc.contributor.authorJessberger, Rolf
dc.contributor.authorOchando, Jordi
dc.contributor.authorDing, Yaozhong
dc.contributor.authorBromberg, Jonathan S
dc.contributor.funderMinisterio de Educación y Ciencia (España)
dc.contributor.funderNational Institutes of Health (Estados Unidos)
dc.contributor.funderAlberta Emerald Foundation
dc.date.accessioned2019-10-25T10:29:24Z
dc.date.available2019-10-25T10:29:24Z
dc.date.issued2009-03-20
dc.description.abstractTo determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands. In the allograft, Treg cells were activated and subsequently migrated to the draining lymph nodes (dLNs) in a CCR2, CCR5, and CCR7 fashion; this movement was essential for optimal suppression. Treg cells inhibited dendritic cell migration in a TGF-beta and IL-10 dependent fashion and suppressed antigen-specific T effector cell migration, accumulation, and proliferation in dLNs and allografts. These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function.es_ES
dc.description.sponsorshipThis work was supported by NIH R01 AI-44929, NIH R01 AI-62765, JDRF 1-2005-16, and the Emerald Foundation (all to JSB); NIH K08 AI071038 (to BS); and the Ministerio de Educación y Ciencia, Spain SAF2007-63579 (to JCO).es_ES
dc.format.number3es_ES
dc.format.page458-69es_ES
dc.format.volume30es_ES
dc.identifier.citationImmunity. 2009 Mar 20;30(3):458-69es_ES
dc.identifier.doi10.1016/j.immuni.2008.12.022es_ES
dc.identifier.e-issn1097-4180es_ES
dc.identifier.issn1074-7613es_ES
dc.identifier.journalImmunityes_ES
dc.identifier.otherhttps://pmc.ncbi.nlm.nih.gov/articles/PMC2737741/
dc.identifier.pubmedID19303390es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8531
dc.language.isoenges_ES
dc.publisherElsevier
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MEC//SAF2007-63579/ES/MECANISMOS DE INDUCCION DE TOLERANCIA A TRANSPLANTES/
dc.relation.publisherversionhttps://doi.org/10.1016/j.immuni.2008.12.022es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalses_ES
dc.subject.meshAutoimmunityes_ES
dc.subject.meshCell Movementes_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshDendritic Cellses_ES
dc.subject.meshInflammationes_ES
dc.subject.meshIslets of Langerhanses_ES
dc.subject.meshLymph Nodeses_ES
dc.subject.meshLymphocyte Subsetses_ES
dc.subject.meshMicees_ES
dc.subject.meshMice, Inbred BALB Ces_ES
dc.subject.meshMice, Inbred C57BLes_ES
dc.subject.meshReverse Transcriptase Polymerase Chain Reactiones_ES
dc.subject.meshT-Lymphocytes, Regulatoryes_ES
dc.titleRegulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune responsees_ES
dc.typeresearch articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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