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Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus

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dc.contributor.authorde la Visitación, Néstor
dc.contributor.authorRobles-Vera, Iñaki
dc.contributor.authorToral, Marta
dc.contributor.authorDuarte, Juan
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.date.accessioned2020-01-29T11:49:11Z
dc.date.available2020-01-29T11:49:11Z
dc.date.issued2019-11-05
dc.description.abstractThe prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota, preventing SLE progression. The aim of this review is to explore the role of the gut microbiota in the development of renal and cardiovascular disease in SLE and how probiotics could be a therapeutic option. Despite strong evidence on the beneficial effects of probiotics in the development of autoimmunity and nephritis in SLE, only a few studies described the protective effects of Lactobacillus in important risk factors for CVD, such as endothelial dysfunction and hypertension in mice. The preventive effects of probiotics in renal and CVD in humans have not been established yet.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by grants from Comisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad (MINECO) (SAF2014-55523-R, SAF2017-84894-R) and Junta de Andalucía (Proyecto de excelencia P12-CTS-2722, and CTS 164), with funds from the European Union, and by the Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV). I.R.-V. is a predoctoral fellow of MINECO; N.d.l.V. is a predoctoral fellow of Junta de Andalucía and Fondo Social Europeo “FEDER una manera de hacer Europa”, and M.T. is a postdoctoral fellow of Instituto de Salud Carlos III (Sara Borrell Program).es_ES
dc.format.number11es_ES
dc.format.page2676es_ES
dc.format.volume11es_ES
dc.identifier.citationNutrients. 2019; 11(11):e2676es_ES
dc.identifier.doi10.3390/nu11112676es_ES
dc.identifier.e-issn2072-6643es_ES
dc.identifier.issn2072-6643es_ES
dc.identifier.journalNutrientses_ES
dc.identifier.pubmedID31694260es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8976
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu11112676es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Génica en Remodelado Vascular e Inflamaciónes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEndothelial dysfunctiones_ES
dc.subjectGut microbiotaes_ES
dc.subjectHypertensiones_ES
dc.subjectImmune responsees_ES
dc.subjectNephritises_ES
dc.titleProtective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosuses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication3775484d-976b-4675-aab3-c82c2205ad1e
relation.isAuthorOfPublication.latestForDiscovery3775484d-976b-4675-aab3-c82c2205ad1e

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