Publication:
Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

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dc.contributor.authorKapoor, Pooja Middha
dc.contributor.authorMavaddat, Nasim
dc.contributor.authorChoudhury, Parichoy Pal
dc.contributor.authorWilcox, Amber N
dc.contributor.authorLindström, Sara
dc.contributor.authorBehrens, Sabine
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorDennis, Joe
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Qin
dc.contributor.authorJung, Audrey
dc.contributor.authorAbu-Ful, Zomoroda
dc.contributor.authorAhearn, Thomas
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorArndt, Volker
dc.contributor.authorAronson, Kristan J
dc.contributor.authorAuer, Paul L
dc.contributor.authorFreeman, Laura E Beane
dc.contributor.authorBecher, Heiko
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorBeeghly-Fadiel, Alicia
dc.contributor.authorBenitez, Javier
dc.contributor.authorBernstein, Leslie
dc.contributor.authorBojesen, Stig E
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBrüning, Thomas
dc.contributor.authorCai, Qiuyin
dc.contributor.authorCampa, Daniele
dc.contributor.authorCanzian, Federico
dc.contributor.authorCarracedo, Ángel
dc.contributor.authorCarter, Brian D
dc.contributor.authorCastelao, Jose E
dc.contributor.authorChanock, Stephen J
dc.contributor.authorChatterjee, Nilanjan
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorClarke, Christine L
dc.contributor.authorCouch, Fergus J
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S
dc.contributor.authorCzene, Kamila
dc.contributor.authorDai, James Y
dc.contributor.authorEarp, H Shelton
dc.contributor.authorEkici, Arif B
dc.contributor.authorEliassen, A Heather
dc.contributor.authorEriksson, Mikael
dc.contributor.authorEvans, D Gareth
dc.contributor.authorFasching, Peter A
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorFritschi, Lin
dc.contributor.authorGabrielson, Marike
dc.contributor.authorGago-Dominguez, Manuela
dc.contributor.authorGao, Chi
dc.contributor.authorGapstur, Susan M
dc.contributor.authorGaudet, Mia M
dc.contributor.authorGiles, Graham G
dc.contributor.authorGonzález-Neira A, Anna
dc.contributor.authorGuénel, Pascal
dc.contributor.authorHaeberle, Lothar
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorHåkansson, Niclas
dc.contributor.authorHall, Per
dc.contributor.authorHamann, Ute
dc.contributor.authorHatse, Sigrid
dc.contributor.authorHeyworth, Jane
dc.contributor.authorHolleczek, Bernd
dc.contributor.authorHoover, Robert N
dc.contributor.authorHopper, John L
dc.contributor.authorHowell, Anthony
dc.contributor.authorHunter, David J
dc.contributor.authorJohn, Esther M
dc.contributor.authorJones, Michael E
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKeeman, Renske
dc.contributor.authorKitahara, Cari M
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorKoutros, Stella
dc.contributor.authorKurian, Allison W
dc.contributor.authorLambrechts, Diether
dc.contributor.authorMarchand, Loic Le
dc.contributor.authorLee, Eunjung
dc.contributor.authorLejbkowicz, Flavio
dc.contributor.authorLinet, Martha
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLlaneza, Ana
dc.contributor.authorMacInnis, Robert J
dc.contributor.authorMartinez, Maria Elena
dc.contributor.authorMaurer, Tabea
dc.contributor.authorMcLean, Catriona
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorNewman, William G
dc.contributor.authorNorman, Aaron
dc.contributor.authorO'Brien, Katie M
dc.contributor.authorOlshan, Andrew F
dc.contributor.authorOlson, Janet E
dc.contributor.authorOlsson, Håkan
dc.contributor.authorOrr, Nick
dc.contributor.authorPerou, Charles M
dc.contributor.authorPita, Guillermo
dc.contributor.authorPolley, Eric C
dc.contributor.authorPrentice, Ross L
dc.contributor.authorRennert, Gad
dc.contributor.authorRennert, Hedy S
dc.contributor.authorRuddy, Kathryn J
dc.contributor.authorSandler, Dale P
dc.contributor.authorSaunders, Christobel
dc.contributor.authorSchoemaker, Minouk J
dc.contributor.authorSchöttker, Ben
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorScott, Christopher
dc.contributor.authorScott, Rodney J
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorSmeets, Ann
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorSpinelli, John J
dc.contributor.authorStone, Jennifer
dc.contributor.authorSwerdlow, Anthony J
dc.contributor.authorTamimi, Rulla M
dc.contributor.authorTaylor, Jack A
dc.contributor.authorTroester, Melissa A
dc.contributor.authorVachon, Celine M
dc.contributor.authorvan Veen, Elke M
dc.contributor.authorWang, Xiaoliang
dc.contributor.authorWeinberg, Clarice R
dc.contributor.authorWeltens, Caroline
dc.contributor.authorWillett, Walter
dc.contributor.authorWinham, Stacey J
dc.contributor.authorWolk, Alicja
dc.contributor.authorYang, Xiaohong R
dc.contributor.authorZheng, Wei
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorDunning, Alison M
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorKraft, Peter
dc.contributor.authorEaston, Douglas F
dc.contributor.authorMilne, Roger L
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorChang-Claude, Jenny
dc.date.accessioned2020-05-04T16:35:13Z
dc.date.available2020-05-04T16:35:13Z
dc.date.issued2020-05-02
dc.description.abstractWe evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.es_ES
dc.description.peerreviewedSíes_ES
dc.identifier.citationJ Natl Cancer Inst . 2020 ;djaa056.es_ES
dc.identifier.doi10.1093/jnci/djaa056es_ES
dc.identifier.e-issn1460-2105es_ES
dc.identifier.issn0027-8874es_ES
dc.identifier.journalJournal of the National Cancer Institutees_ES
dc.identifier.pubmedID32359158es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9872
dc.language.isoenges_ES
dc.publisherOxford University Press
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI11/00923es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/ PI12/00070es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI13/00061es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI13/01162es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/jnci/djaa056.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Genética Humanaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBreast canceres_ES
dc.subjectEpidemiologyes_ES
dc.subjectGene-environment interactionses_ES
dc.subjectGenetic susceptibilityes_ES
dc.subjectPolygenic risk scorees_ES
dc.subjectRisk factorses_ES
dc.subjectRisk predictiones_ES
dc.titleCombined associations of a polygenic risk score and classical risk factors with breast cancer riskes_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication533f89d5-8c60-4f00-8559-16f5ea8ae0e0
relation.isAuthorOfPublication.latestForDiscovery533f89d5-8c60-4f00-8559-16f5ea8ae0e0
relation.isPublisherOfPublication465a0b1e-d9df-4342-b738-86ffcafc4bcf
relation.isPublisherOfPublication.latestForDiscovery465a0b1e-d9df-4342-b738-86ffcafc4bcf

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IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela (Galicia)