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First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain

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URI: http://hdl.handle.net/20.500.12105/8793
ISSN: 2052-2975
DOI: 10.1016/j.nmni.2015.04.005

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2015-07

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Wiley
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Abstract

We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance.

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Corrigendum to "First detection of Aspergillus fumigatus azole resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain". (New Microbes New Infect 6 (2015) 33-34). New Microbes New Infect. 2016 May 6;13:59. doi: 10.1016/j.nmni.2016.04.009. PMID: 27408747.

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Aspergillus fumigatus Azole resistance spread cyp51A Resistance mechanism

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New Microbes New Infect. 2015 Apr 20;6:33-4.

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Centro Nacional de Microbiología (CNM)
IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)

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https://doi.org/10.1016/j.nmni.2015.04.005

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research article