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Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids

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dc.contributor.authorTorrens-Mas, Margalida
dc.contributor.authorPerelló-Campaner, Catalina
dc.contributor.authorNavas-Enamorado, Cayetano
dc.contributor.authorIbarguen-Gonzalez, Lesly
dc.contributor.authorSanchez-Polo, Andrés
dc.contributor.authorSegura-Sampedro, Juan José
dc.contributor.authorMasmiquel Comas, Lluis
dc.contributor.authorBarceló, Carles
dc.contributor.authorGonzalez-Freire, Marta
dc.date.accessioned2024-09-18T06:43:52Z
dc.date.available2024-09-18T06:43:52Z
dc.date.issued2021-10
dc.description.abstractThe biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans, and cell cultures. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. An organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging, and to design personalized approaches for the prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging, paving the way to personalized interventions targeting the biology of aging.en
dc.description.sponsorshipThis research was funded by theMiguel Servet program (MS19/00201 and MS19/00100) (M.G.F. and C.B.), Instituto de Salud Carlos III (ISCIII), Madrid; the Health Research grant-ISCIII (PI20/01267) (C.B.); COVID grant-ISCIII (COV20/00571) (C.B.); the Margalida Comas program(PD/050/2020), Comunidad Autonoma de las Islas Baleares (M.T.M); the FOLIUM fellowship program (FOLIUM19/01), Impost turisme sostenible/Govern de les Illes Balears (C.M.P.R.); and the TECH fellowship program, Impost turisme sostenible/Govern de les Illes Balears (TECH19/03) (L.Y.G).es_ES
dc.format.number19es_ES
dc.format.page10547es_ES
dc.format.volume22es_ES
dc.identifier.citationTorrens-Mas M, Perello-Reus C, Navas-Enamorado C, Ibarguen-Gonzalez L, Sanchez-Polo A, Segura-Sampedro JJ, et al. Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids. Int J Mol Sci. 2021 Oct;22(19):10547.en
dc.identifier.doi10.3390/ijms221910547
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational Journal of Molecular Scienceses_ES
dc.identifier.otherhttps://hdl.handle.net/20.500.13003/19732
dc.identifier.pubmedID34638891es_ES
dc.identifier.puiL2013955821
dc.identifier.scopus2-s2.0-85116074089
dc.identifier.urihttps://hdl.handle.net/20.500.12105/23293
dc.identifier.wos775542200009
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://dx.doi.org/10.3390/ijms221910547en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOrganoids
dc.subjectAging
dc.subjectPrecision medicine
dc.subject.decsAnimales*
dc.subject.decsModelos Genéticos*
dc.subject.decsGenómica*
dc.subject.decsEnvejecimiento*
dc.subject.decsHumanos*
dc.subject.decsNeoplasias*
dc.subject.decsInestabilidad Genómica*
dc.subject.decsEpigenómica*
dc.subject.decsOrganoides*
dc.subject.decsTécnicas de Cultivo de Célula*
dc.subject.meshCell Culture Techniques*
dc.subject.meshEpigenomics*
dc.subject.meshGenomics*
dc.subject.meshAnimals*
dc.subject.meshModels, Genetic*
dc.subject.meshHumans*
dc.subject.meshGenomic Instability*
dc.subject.meshAging*
dc.subject.meshNeoplasms*
dc.subject.meshOrganoids*
dc.titleOrganoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoidsen
dc.typereview articleen
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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