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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.

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dc.contributor.authorBecker, Annette
dc.contributor.authorThakur, Basant Kumar
dc.contributor.authorWeiss, Joshua Mitchell
dc.contributor.authorKim, Han Sang
dc.contributor.authorPeinado, Hector
dc.contributor.authorLyden, David
dc.date.accessioned2024-02-12T12:25:41Z
dc.date.available2024-02-12T12:25:41Z
dc.date.issued2016-12-12
dc.description.abstractTumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipAcknowledgments The authors gratefully acknowledge support from the following funding sources: the National Cancer Institute (CA169538 and CA169416 to D.L and H.P.), the Department of Defense (W81XWH-13-1-0427, W81XWH-13-1-0249 and W81XWH-14-1-0199 to D.L), the Hartwell Foundation, The Manning Foundation, The Sohn Foundation, The STARR Consortium, The POETIC Consortium, the Paduano Foundation, Alex's Lemonade Stand Foundation, the Champalimaud Foundation (all to D.L), and the Daedalus Fund (Weill Cornell Medicine, to D.L). H.P. is supported by grants from MINECO (SAF2014-54541-R), ATRES-MEDIA – AXA, Asociación Española Contra el Cáncer, WHRI Academy, and Worldwide Cancer Research. B.K.T. was supported by the Jose Carreras Leukaemia Foundation (DJCLS R12/06). H.S.K is supported by a Physician-Scientist Program from the Yonsei University College of Medicine. J.M.W. is supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the National Institutes of Health (T32GM007739). The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.es_ES
dc.format.number6es_ES
dc.format.page836es_ES
dc.format.volume30es_ES
dc.identifier.citationCancer Cell . 2016;30(6):836-848.es_ES
dc.identifier.doi10.1016/j.ccell.2016.10.009es_ES
dc.identifier.e-issn1878-3686es_ES
dc.identifier.journalCancer celles_ES
dc.identifier.pmchttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC
dc.identifier.pubmedID27960084es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17974
dc.language.isoenges_ES
dc.publisherCell Press
dc.relation.publisherversionhttps://doi.org/10.1016/j.ccell.2016.10.009es_ES
dc.repisalud.institucionCNIOes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshBiomarkers, Tumores_ES
dc.subject.meshCell Communicationes_ES
dc.subject.meshExosomeses_ES
dc.subject.meshExtracellular Vesicleses_ES
dc.subject.meshHumanses_ES
dc.subject.meshNeoplasm Metastasises_ES
dc.subject.meshNeoplasmses_ES
dc.subject.meshPrognosises_ES
dc.subject.meshTumor Microenvironmentes_ES
dc.titleExtracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isPublisherOfPublicationaea619d1-42a6-47f8-84e2-6bc27d6f8300
relation.isPublisherOfPublication.latestForDiscoveryaea619d1-42a6-47f8-84e2-6bc27d6f8300

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