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TRIM25 in the Regulation of the Antiviral Innate Immunity

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dc.contributor.authorMartin-Vicente, Maria
dc.contributor.authorMedrano, Luz Maria
dc.contributor.authorResino, Salvador
dc.contributor.authorGarcía-Sastre, Adolfo
dc.contributor.authorMartinez, Isidoro
dc.contributor.funderInstituto de Salud Carlos III
dc.date.accessioned2019-02-19T10:05:07Z
dc.date.available2019-02-19T10:05:07Z
dc.date.issued2017-09
dc.description.abstractTRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the melanoma differentiation-associated protein 5-mitochondrial antiviral signaling protein-TRAF6 antiviral axis and modulation of p53 levels and activity. In addition, the ability of TRIM25 to bind RNA may uncover new mechanisms by which this molecule regulates intracellular signaling and/or RNA virus replication.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipWe gratefully acknowledge financial support from Instituto de Salud Carlos III, grant numbers PI15CIII/00024 (IM), PI14CIII/00011 (SR), and CD14/00002 (LM). AG-S laboratories are partly supported by NIH grants R33AI119304, R21AI129486, U19AI106754, P01AI097092, R01DA033773, R01AI088770, U19AI117873, U19AI118610, R01AI125524, U01AI124297, and R01AI127658, contract HHSN272201300023C and by CRIP (Center for Research on Influenza Pathogenesis), an NIAID funded Center of Excellence for Influenza Surveillance and Research (CEIRS, contract HHSN272201400008C).es_ES
dc.format.page1187es_ES
dc.format.volume8es_ES
dc.identifier.citationFront Immunol. 2017 Sep 22;8:1187es_ES
dc.identifier.doi10.3389/fimmu.2017.01187es_ES
dc.identifier.issn1664-3224es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.identifier.pubmedID29018447es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7180
dc.language.isoenges_ES
dc.publisherFrontiers Media
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15CIII/00024es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14CIII/00011es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD14/00002es_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2017.01187es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectE3 ubiquitin ligasees_ES
dc.subjectTRIM25es_ES
dc.subjectInnate immunityes_ES
dc.subjectUbiquitinationes_ES
dc.subjectViruses_ES
dc.titleTRIM25 in the Regulation of the Antiviral Innate Immunityes_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
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