Browsing by MeSH term "Lipopolysaccharide Receptors"
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Publication Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study(Nature Publishing Group, 2018) Jimenez-Sousa, Maria Angeles; Liu, Pilar; Medrano, Luz Maria; Fernandez-Rodriguez, Amanda; Almansa, Raquel; Gómez-Sánchez, Esther; Rico, Lucía; Lorenzo, Mario; Fadrique, Alejandra; Tamayo, Eduardo; Resino, Salvador; Instituto de Salud Carlos III; Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF); Junta de Castilla y León (España)The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.Publication TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity.(Nature Publishing Group, 2018) Riquelme, Paloma; Haarer, Jan; Kammler, Anja; Walter, Lisa; Tomiuk, Stefan; Ahrens, Norbert; Wege, Anja K; Goecze, Ivan; Zecher, Daniel; Banas, Bernhard; Spang, Rainer; Fändrich, Fred; Lutz, Manfred B; Sawitzki, Birgit; Schlitt, Hans J; Ochando, Jordi; Geissler, Edward K; Hutchinson, James A; Unión Europea. Comisión Europea. 7 Programa Marco; Deutsche Forschungsgemeinschaft (Alemania); Unión Europea. Comisión Europea. H2020Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced regulatory T cells that non-specifically suppress bystander T cells and inhibit dendritic cell maturation. Differentiation of Mreg-induced Tregs relies on multiple non-redundant mechanisms that are not exclusive to interaction of Mregs and T cells, including signals mediated by indoleamine 2,3-dioxygenase, TGF-β, retinoic acid, Notch and progestagen-associated endometrial protein. Preoperative administration of donor-derived Mregs to living-donor kidney transplant recipients results in an acute increase in circulating TIGIT+ Tregs. These results suggest a feed-forward mechanism by which Mreg treatment promotes allograft acceptance through rapid induction of direct-pathway Tregs.