Browsing by Author "Gaudet, Mia M."
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Publication A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.(Nature Publishing Group, 2020-11-01) Escala-Garcia, Maria; Abraham, Jean; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Ashworth, Alan; Auer, Paul L; Auvinen, Päivi; Beckmann, Matthias W; Beesley, Jonathan; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Blot, William; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brucker, Sara Y; Burwinkel, Barbara; Caldas, Carlos; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J; Chin, Suet-Feung; Clarke, Christine L; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Dennis, Joe; Devilee, Peter; Dunn, Janet A; Dunning, Alison M; Dwek, Miriam; Earl, Helena M; Eccles, Diana M; Eliassen, A Heather; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; García-Closas, Montserrat; García-Sáenz, José A; Gaudet, Mia M; George, Angela; Giles, Graham G; Goldgar, David E; González-Neira, Anna; Grip, Mervi; Guénel, Pascal; Guo, Qi; Haiman, Christopher A; Håkansson, Niclas; Hamann, Ute; Harrington, Patricia A; Hiller, Louise; Hooning, Maartje J; Hopper, John L; Howell, Anthony; Huang, Chiun-Sheng; Huang, Guanmengqian; Hunter, David J; Jakubowska, Anna; John, Esther M; Kaaks, Rudolf; Kapoor, Pooja Middha; Keeman, Renske; Kitahara, Cari M; Kraft, Peter; Lambrechts, Diether; Le Marchand, Loic; Lejbkowicz, Flavio; Lindblom, Annika; Lubiński, Jan; Mannermaa, Arto; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Maria Elena; Maurer, Tabea; Mavroudis, Dimitrios; Meindl, Alfons; Milne, Roger L; Mulligan, Anna Marie; Neuhausen, Susan L; Nevanlinna, Heli; Newman, William G; Olshan, Andrew F; Olson, Janet E; Olsson, Håkan; Orr, Nick; Peterlongo, Paolo; Petridis, Christos; Prentice, Ross L; Presneau, Nadege; Punie, Kevin; Ramachandran, Dhanya; Rennert, Gad; Romero, Atocha; Sachchithananthan, Mythily; Saloustros, Emmanouil; Sawyer, Elinor J; Schmutzler, Rita K; Schwentner, Lukas; Scott, Christopher; Simard, Jacques; Sohn, Christof; Southey, Melissa C; Swerdlow, Anthony J; Tamimi, Rulla M; Tapper, William J; Teixeira, Manuel R; Terry, Mary Beth; Thorne, Heather; Tollenaar, Rob A E M; Tomlinson, Ian; Troester, Melissa A; Truong, Thérèse; Turnbull, Clare; Vachon, Celine M; van der Kolk, Lizet E; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R; Ziogas, Argyrios; Pharoah, Paul D P; Hall, Per; Wessels, Lodewyk F A; Chenevix-Trench, Georgia; Bader, Gary D; Dörk, Thilo; Easton, Douglas F; Canisius, Sander; Schmidt, Marjanka K; Gonzalez Neira, Anna; Andrulis, Irene L.; Auer, Paul L.; Beckmann, Matthias W.; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Brucker, Sara Y.; Chanock, Stephen J.; Clarke, Christine L.; Couch, Fergus J.; Cross, Simon S.; Daly, Mary B.; Dunn, Janet A.; Dunning, Alison M.; Earl, Helena M.; Eccles, Diana M.; Eliassen, A. Heather; Evans, D. Gareth; Fasching, Peter A.; Gapstur, Susan M.; García-Sáenz, José A.; Gaudet, Mia M.; Giles, Graham G.; Goldgar, David E.; Haiman, Christopher A.; Harrington, Patricia A.; Hooning, Maartje J.; Hopper, John L.; Hunter, David J.; John, Esther M.; Kitahara, Cari M.; Koppert, Linetta B; Kristensen, Vessela N; Milne, Roger L.; Neuhausen, Susan L.; Newman, William G.; Olshan, Andrew F.; Olson, Janet E.; Prentice, Ross L.; Sawyer, Elinor J.; Schmutzler, Rita K.; Southey, Melissa C.; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Tollenaar, Rob A. E. M.; Troester, Melissa A.; Vachon, Celine M.; van der Kolk, Lizet E.; Yang, Xiaohong R.; Pharoah, Paul D. P.; Wessels, Lodewyk F. A.; Bader, Gary D.; Easton, Douglas F.; Schmidt, Marjanka K.; National Institute for Health Research (Reino Unido); German Cancer Research Center; United States Department of Health and Human Services; Cancer Research UK (Reino Unido); Unión Europea. Comisión Europea; Canadian Institutes of Health Research; Ministere de l'Economie, Science et Innovation du Quebec (Canadá); Dutch Cancer Society (Holanda); Instituto de Salud Carlos III; Asociación Española Contra el Cáncer; Deutsche Krebshilfe; Russian Foundation for Basic Research; Swedish Research Council; Breast Cancer Now (Reino Unido)Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.