Montero-Calle, Ana MariaGarranzo-Asensio, MariaMoreno-Casbas, TeresaCampuzano, SusanaBarderas Manchado, Rodrigo2024-10-142024-10-142024Front Immunol. 2024 Aug 21:15:1455602.https://hdl.handle.net/20.500.12105/25096Although blood autoantibodies were initially associated with autoimmune diseases, multiple evidence have been accumulated showing their presence in many types of cancer. This has opened their use in clinics, since cancer autoantibodies might be useful for early detection, prognosis, and monitoring of cancer patients. In this review, we discuss the different techniques available for their discovery and validation. Additionally, we discuss here in detail those autoantibody panels verified in at least two different reports that should be more likely to be specific of each of the four most incident cancers. We also report the recent developed kits for breast and lung cancer detection mostly based on autoantibodies and the identification of novel therapeutic targets because of the screening of the cancer humoral immune response. Finally, we discuss unsolved issues that still need to be addressed for the implementation of cancer autoantibodies in clinical routine for cancer diagnosis, prognosis, and/or monitoring.engVoRhttp://creativecommons.org/licenses/by/4.0/AutoantibodiesBreast cancerCancer autoantibodiesColorectal cancerHumoral immune responseLung cancerProstate cancerProteomicsAnimalsAutoantibodiesBiomarkers, TumorEarly Detection of CancerHumansNeoplasmsPrognosisAttribution 4.0 International3923424715145560210.3389/fimmu.2024.14556021664-3224Frontiers in immunologyopen access