Perez-de-Llano, LuisGarcía-Cosío, BorjaCHACOS Study Grp2024-07-112024-07-112017-11-02Perez-De-Llano L, Cosio BG, CHACOS Study Grp. Asthma-COPD overlap is not a homogeneous disorder: further supporting data. Respir Res. 2017 Nov 02;18:183.1465-993Xhttp://hdl.handle.net/20.500.13003/9560http://hdl.handle.net/20.500.12105/20462Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-alpha, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions.enghttp://creativecommons.org/licenses/by/4.0/EosinophilsPeriostinCOPDAsthmaAsthma-COPD overlapACOAsthmaEosinophilsAgedMaleInflammation MediatorsFemalePulmonary Disease, Chronic ObstructiveHumansForced Expiratory VolumeMiddle AgedCross-Sectional Studiesresearch articleAttribution 4.0 International290966091818310.1186/s12931-017-0667-x1465-9921Respiratory Researchopen accessEstudios TransversalesVolumen Espiratorio ForzadoEnfermedad Pulmonar Obstructiva CrónicaHumanosMediadores de InflamaciónPersona de Mediana EdadAncianoAsmaEosin�filosFemeninoMasculino2-s2.0-85032744946414334100002L619046921