Jimenez-Sousa, Maria AngelesFadrique, AlejandraLiu, PilarFernandez-Rodriguez, AmandaLorenzo-López, MarioGómez-Sánchez, EstherGomez-Sanz, AliciaHeredia-Rodríguez, MaríaGómez-Pesquera, EstefaníaMartinez, IsidoroTamayo, EduardoResino, Salvador2020-01-152020-01-152019-02-26J Clin Med. 2019 Feb 26;8(3). pii: E283.2077-0383http://hdl.handle.net/20.500.12105/8895BACKGROUND: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. METHODS: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience's MassARRAY platform. RESULTS: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. CONCLUSIONS: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery.engVoRhttp://creativecommons.org/licenses/by/4.0/MyD88SNPsTNFAIP3TNIP1Major surgerySeptic shockSurvivalAtribución 4.0 Internacional308135928328310.3390/jcm8030283Journal of clinical medicineopen access