Ferrer, Miguel DBusquets-Cortés, CarlaCapó Fiol, XavierTejada Gavela, SilviaTur, Josep APons, AntoniSoldevila Verdeguer, Carla2024-09-102024-09-102019Ferrer Miguel D., Busquets-Cortes Carla, Capo Fiol Xavier, Tejada Gavela Silvia, Tur Josep, Pons Antoni, et al. Cyclooxygenase-2 Inhibitors as a Therapeutic Target in Inflammatory Diseases. Curr Med Chem. 2019;26(18):3225-3241.0929-8673http://hdl.handle.net/20.500.13003/8927https://hdl.handle.net/20.500.12105/22650Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies. Prostaglandins play a regulatory role in inflammation. Cyclooxygenases are the main mediators of inflammation by catalyzing the initial step of arachidonic acid metabolism and prostaglandin synthesis. The differential expression of the constitutive isoform COX-1 and the inducible isoform COX-2, and the finding that COX-1 is the major form expressed in the gastrointestinal tract, lead to the search for COX-2-selective inhibitors as anti-inflammatory agents that might diminish the gastrointestinal side effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs). COX-2 isoform is expressed predominantly in inflammatory cells and decidedly upregulated in chronic and acute inflammations, becoming a critical target for many pharmacological inhibitors. COX-2 selective inhibitors happen to show equivalent efficacy with that of conventional NSAIDs, but they have reduced gastrointestinal side effects. This review would elucidate the most recent findings on selective COX-2 inhibition and their relevance to human pathology, concretely in inflammatory pathologies characterized by a prolonged pro-inflammatory status, including autoimmune diseases, metabolic syndrome, obesity, atherosclerosis, neurodegenerative diseases, chronic obstructive pulmonary disease, arthritis, chronic inflammatory bowel disease and cardiovascular pathologies.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/CyclooxygenaseCOX inhibitorsInflammationInterleukinNatural compoundProstaglandinAutoimmune DiseasesMetabolic SyndromePulmonary Disease, Chronic ObstructiveHumansInflammationAnti-Inflammatory Agents, Non-SteroidalArthritisObesityAnimalsInflammatory Bowel DiseasesNeurodegenerative DiseasesAtherosclerosisCyclooxygenase 2 InhibitorsCyclooxygenase 2Attribution-NonCommercial-NoDerivatives 4.0 International2975656326183225-324110.2174/09298673256661805141121241875-533XCurrent Medicinal Chemistryopen accessAnimalesEnfermedades Inflamatorias del IntestinoSíndrome MetabólicoEnfermedades NeurodegenerativasAterosclerosisInhibidores de la Ciclooxigenasa 2Enfermedad Pulmonar Obstructiva CrónicaArtritisHumanosObesidadAntiinflamatorios no EsteroideosInflamaciónCiclooxigenasa 2Enfermedades Autoinmunes2-s2.0-85072347590484009600003L2004249959