Cantero, IreneElorz, MarianaAbete, ItziarAraceli Marin, BerthaIgnacio Herrero, JoseIgnacio Monreal, JoseBenito, AlbertoQuiroga, JorgeMartinez, AnaPilar Huarte, MaIsidro Uriz-Otano, JuanTur, Josep AKearney, JohnAlfredo Martinez, JAngeles Zulet, M2024-09-102024-09-102019Cantero I, Elorz M, Abete I, Marin BA, Herrero JI, Monreal JI, et al. Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults. Int J Med Sci. 2019;16(1):75-83.1449-1907http://hdl.handle.net/20.500.13003/17271https://hdl.handle.net/20.500.12105/22726Introduction: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations. Objective: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease. Materials and methods: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Body composition (DXA), hepatic related biochemical measurements as well as the Fatty Liver Index (FLI) were evaluated. This study was registered as FLiO: Fatty Liver in Obesity study; NCT03183193. Results: The subjects with more severe liver disease were found to have worse metabolic parameters. Positive associations between MRI with inflammatory and insulin biomarkers were found. A linear regression model including ALT, RBP4 and HOMA-IR was able to explain 40.9% of the variability in fat content by MRI. In ROC analyses a combination panel formed of ALT, HOMA-IR and RBP4 followed by ultrasonography, ALT and metabolomic test showed the major predictive ability (77.3%, 74.6%, 74.3% and 71.1%, respectively) for liver fat content. Conclusions: A panel combination including routine blood markers linked to insulin resistance showed highest associations with MRI considered as a gold standard for determining liver fat content. This combination of tests can facilitate the diagnosis of early stages of non-alcoholic liver disease thereby avoiding other invasive and expensive methods.enghttp://creativecommons.org/licenses/by-nc/4.0/MRILiver fat contentUltrasoundROCFibroScanNAFLDAdultInsulinHumansMiddle AgedNon-alcoholic Fatty Liver DiseaseCross-Sectional StudiesInsulin ResistanceMagnetic Resonance ImagingObesityMaleBiomarkersFemaleAdiposityUltrasonographyElasticity Imaging Techniquesresearch articleAttribution-NonCommercial 4.0 International3066233116175-8310.7150/ijms.28044International Journal of Medical Sciencesopen accessUltrasonografíaBiomarcadoresFemeninoEnfermedad del Hígado Graso no AlcohólicoResistencia a la InsulinaImagen por Resonancia MagnéticaMasculinoInsulinaEstudios TransversalesDiagnóstico por Imagen de ElasticidadHumanosPersona de Mediana EdadObesidadAdultoAdiposidad2-s2.0-85060143339454840700010L2001352422