Martínez-Trufero, JavierDe Sande-González, Luis MiguelLuna, PabloMartin-Broto, JavierÁlvarez, RosaMarquina, GloriaDiaz-Beveridge, RobertoPoveda, AndrésCano, Juana MaríaCruz-Jurado, JosefinaLópez Pousa, AntonioVaz Salgado, María AngelesValverde-Morales, Claudia M.Sevilla, IsabelMartínez-García, JerónimoRubio-Casadevall, JordiDe Juan, AnaCarrasco, Juan AntonioMoura, David S.Gurruchaga-Sotes, IbonGutiérrez, Antonio2024-02-192024-02-192021-02-14http://hdl.handle.net/10668/4498http://hdl.handle.net/20.500.12105/18255The aim of this study was to identify an easily reliable prognostic score that selects the subset of advanced soft tissue sarcoma (ASTS) patients with a higher benefit with trabectedin in terms of time to progression and overall survival. A retrospective series of 357 patients with ASTS treated with trabectedin as second- or further-line in 19 centers across Spain was analyzed. First, it was confirmed that patients with high growth modulation index (GMI > 1.33) were associated with the better clinical outcome. Univariate and multivariate analyses were performed to identify factors associated with a GMI > 1.33. Thus, GEISTRA score was based on metastasis free-interval (MFI ≤ 9.7 months), Karnofsky < 80%, Non L-sarcomas and better response in the previous systemic line. The median GMI was 0.82 (0–69), with 198 patients (55%) with a GMI < 1, 41 (11.5%) with a GMI 1–1.33 and 118 (33.1%) with a GMI > 1.33. The lowest GEISTRA score showed a median of time-to-progression (TTP) and overall survival (OS) of 5.7 and 19.5 months, respectively, whereas it was 1.8 and 3.1 months for TTP and OS, respectively, for the GEISTRA 4 score. This prognostic tool can contribute to better selecting candidates for trabectedin treatment in ASTS.engVoRhttp://creativecommons.org/licenses/by/4.0/TrabectedinSarcomaGrowth modulation indexPrognostic scoreL-sarcomaGEISTRASpainAdvanced soft tissue sarcomasTrabectedinaPronósticoLiposarcomaLeiomiosarcomaEspañaHumansPrognosisRetrospective StudiesThiamine TriphosphateSpainSarcomaMultivariate AnalysisLeiomyosarcomaLiposarcomaAttribution 4.0 International3367285710.3390/cancers130407922072-6694Cancersopen access