Perez-Garcia, FelipeVázquez-Morón, SoniaBurgueño-García, IvánMuñoz-Gómez, María JoséZea-Sevilla, María AscensiónCalero, MiguelMartinez, IsidoroRábano, AlbertoResino, Salvador2024-01-242024-01-242023-04-12J Infect Dis. 2023 Apr 12;227(7):873-877.http://hdl.handle.net/20.500.12105/17363In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people.engSMURAlzheimerHepatitis E virusNeurodegenerative disordersOlder peopleSeroprevalenceVascular pathologyHepatitis E virusHepatitis ENeurodegenerative DiseasesDementiaHumansAgedSeroepidemiologic StudiesCase-Control StudiesHepatitis AntibodiesImmunoglobulin MAttribution-NonCommercial-NoDerivatives 4.0 Internacional357592202277873-87710.1093/infdis/jiac2681537-6613The Journal of infectious diseasesopen access