Val-Blasco, AlmudenaPrieto, PatriciaJaén, Rafael IñigoGil-Fernández, MartaPajares, MartaDomenech, NievesTerrón, VerónicaTamayo, MaríaJorge, InmaculadaVazquez, JesusBueno-Sen, AndreaVallejo-Cremades, María TeresaPombo-Otero, JorgeSanchez-García, SergioRuiz-Hurtado, GemaGómez, Ana MaríaZaragoza, CarlosCrespo-Leiro, María GenerosaLópez-Collazo, EduardoCuadrado, AntonioDelgado, CarmenBoscá, LisardoFernández-Velasco, María2023-04-112023-04-112022-06JACC Basic Transl Sci. 2022 May 18; 7(6):544-560http://hdl.handle.net/20.500.12105/15753Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum-adenosine triphosphatase 2A down-regulation and Ca2+ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacional358185047654410.1016/j.jacbts.2022.01.0092452-302XJACC. Basic to translational scienceopen access