Guzman-Fulgencio, MariaGarcia-Alvarez, MonicaBerenguer, JuanJimenez-Sousa, Maria AngelesCosín, JaimePineda-Tenor, DanielAldámiz-Echevarria, TeresaAlvarez, EmilioLópez, Juan CarlosResino, Salvador2024-01-192024-01-192014-02J Infect. 2014 Feb;68(2):176-84.http://hdl.handle.net/20.500.12105/17237Objective: To study the association of plasma 25-hydroxy vitamin D (25(OH)D) levels in HIV/HCV coinfected patients with severity of liver disease and virological response to hepatitis C virus (HCV) therapy with pegylated-interferon-alpha plus ribavirin (pegIFNα/RBV). Methods: A cross-sectional study in 174 HIV/HCV coinfected patients that underwent a liver biopsy previously to start HCV therapy and a retrospective study of 125 of them. Plasma 25(OH)D levels were quantified by enzyme immunoassay. Liver biopsies were evaluated by METAVIR score. A sustained virological response (SVR) was defined as an undetectable serum HCV viral load (<10 IU/mL) up through 24 weeks after the end of HCV treatment. Results: The median of plasma 25(OH)D level was 48 nmol/L (p25th: 32.5; p75th: 56.1) and 27 (15.5%) had 25(OH)D deficiency (<25 nmol/L). The percentage of 25(OH)D deficiency was higher in patients with significant fibrosis (F ≥ 2) (92.6% vs. 57.1%; p = 0.010) and moderate necroinflammatory activity grade (A ≥ 2) (85.2% vs. 60%; p = 0.043). However, adjusted logistic regression analyses showed that 25(OH)D deficiency was only associated with severity of liver disease [F ≥ 2 (OR = 8.47 (95% of confidence interval (CI) = 1.88; 38.3); p = 0.005) and A ≥ 2 (OR = 3.25 (95%CI = 1.06; 10.1); p = 0.040)]. Moreover, any significant relationship was found between 25(OH)D deficiency and SVR after HCV therapy. Conclusion: Plasma 25(OH)D deficiency was associated with liver disease severity in HIV/HCV coinfected patients, but it was not associated with HCV treatment failure.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/Vitamin DAIDSChronic hepatitis CLiver fibrosisHepatic biopsyAntiviral therapyAdultAntiviral AgentsCross-Sectional StudiesFemaleHIV InfectionsHepatitis C, ChronicHumansLiver CirrhosisLogistic ModelsMaleMiddle AgedVitamin DVitamin D DeficiencyAttribution-NonCommercial-NoDerivatives 4.0 Internacional24184809682176-18410.1016/j.jinf.2013.10.0111532-2742The Journal of infectionopen access