Martínez-Sanz, JavierJiménez, DanielMartínez-Campelo, LauraCruz, RaquelVizcarra, PilarSánchez-Conde, MatildeRon, RaquelRodríguez, MarioHerrera, SabinaMoreno, SantiagoLopez-Huertas, Maria RosaSerrano-Villar, Sergio2022-03-252022-03-252021-12Emerg Microbes Infect. 2021 Dec;10(1):493-496.http://hdl.handle.net/20.500.12105/13823We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.engVoRCOVID-19SARS-CoV-2Genetic variantsSingle-nucleotide polymorphismSusceptibilityGenetic Predisposition to DiseaseHealth PersonnelPolymorphism, Single NucleotideSARS-CoV-2AdultAgedAtribución-NoComercial 4.0 Internacional33704002101493-49610.1080/22221751.2021.19027552222-1751Emerging Microbes & Infectionsopen access