Ledesma, JuanMuñoz, PGarcía de Viedma, DCabrero, ILoeches, BMontilla, PGijon, PRodriguez-Sanchez, BBouza, EmilioBKV Study Group2025-01-272025-01-272012-07Ledesma J, Muñoz P, Garcia de Viedma D, Cabrero I, Loeches B, Montilla P, Gijon P, Rodriguez-Sanchez B, Bouza E; BKV Study Group. BK virus infection in human immunodeficiency virus-infected patients. Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1531-5.0934-9723https://hdl.handle.net/20.500.12105/26134The aim of this study is to evaluate the prevalence of BK virus (BKV) infection in HIV-positive patients receiving highly active antiretroviral therapy (HAART) in our hospital. The presence of BKV was analysed in urine and plasma samples from 78 non-selected HIV-infected patients. Clinical data were recorded using a pre-established protocol. We used a nested PCR to amplify a specific region of the BKV T-large antigen. Positive samples were quantified using real-time PCR. Mean CD4 count in HIV-infected patients was 472 cells/mm3 and median HIV viral load was <50 copies/mL. BKV viraemia was detected in only 1 HIV-positive patient, but 57.7% (45 out of 78) had BKV viruria, which was more common in patients with CD4 counts>500 cells/mm3 (74.3% vs 25.7%; p=0.007). Viruria was present in 21.7% of healthy controls (5 out of 23 samples, p=0.02). All viral loads were low (<100 copies/mL), and we could not find any association between BKV infection and renal or neurological manifestations. We provide an update on the prevalence of BKV in HIV-infected patients treated with HAART. BKV viruria was more common in HIV-infected patients; however, no role for BKV has been demonstrated in this population.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/AdultAgedBK VirusDNA, ViralFemaleHIV InfectionsHumansMaleMiddle AgedPlasmaPolymerase Chain ReactionPolyomavirus InfectionsPrevalenceProspective StudiesTumor Virus InfectionsUrineViral LoadAttribution-NonCommercial-NoDerivatives 4.0 International220866553171531-153510.1007/s10096-011-1474-91435-4373European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiologyopen access