Haaskjold, Yngvar LundeBolkan, Håkon AngellKrogh, Kurt ØsthuusJongopi, JamesLundeby, Karen MarieMellesmo, SindreGarces, Pedro San JoseJøsendal, OlaØpstad, ÅsmundSvensen, ErlingZabala Fuentes, Luis MatiasKamara, Alfred SandyRiera, MelchorArranz Izquierdo, JavierRoberts, David PStamper, Paul DAustin, PaulaMoosa, Alfredo JMarke, DennisHassan, ShoaibEide, Geir EgilBerg, AseBlomberg, Bjørn2024-07-092024-07-092016-09Lunde Haaskjold Y, Bolkan HA, Osthuus Krogh K, Jongopi J, Lundeby KM, Mellesmo S, et al. Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014 February 2015. Emerg Infect Dis. 2016 Sep;22(9):1537-44. Epub 2016 Sep 15.1080-6040http://hdl.handle.net/20.500.13003/10215http://hdl.handle.net/20.500.12105/20284The 2013-2016 outbreak of Ebola virus disease (EVD) in West Africa infected >28,000 people, including >11,000 who died, and disrupted social life in the region. We retrospectively studied clinical signs and symptoms and risk factors for fatal outcome among 31 Ebola virus positive patients admitted to the Ebola Treatment Center in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the outbreak. Significant predictors for death were shorter time from symptom onset to admission, male sex, high viral load on initial laboratory testing, severe pain, diarrhea, bloody feces, and development of other bleeding manifestations during hospitalization. These risk factors for death could be used to identify patients in need of more intensive medical support. The lack of fever in as many as one third of EVD cases may have implications for temperature-screening practices and case definitions.enghttp://creativecommons.org/licenses/by/4.0/ChildViral Loadresearch articleAttribution 4.0 International272683032291537-154410.3201/eid2209.1516211080-6059Emerging Infectious Diseasesopen accessFemeninoEbolavirusMortalidadLactanteHistoria del Siglo XXISierra LeonaEvaluación de SíntomasAdolescenteBrotes de EnfermedadesMasculinoPreescolarHumanosPersona de Mediana EdadAdulto JovenVigilancia de la PoblaciónAncianoAnciano de 80 o más AñosFiebre Hemorrágica EbolaNiñoEstudios RetrospectivosAdultoPeriodo de Incubación de Enfermedades InfecciosasCarga Viral2-s2.0-84988432066381955900002L612290680