Gallardo, DavidBosch-Vizcaya, AnnaRodriguez-Romanos, RocioSantos, NazlyBuno, Ismaelde la Cámara, RafaelBrunet, SalutJimenez-Velasco, AntonioGonzalez, MarcosNieto, Jose BMartinez-Laperche, CarolinaVallejo, CarlosFerra, ChristelleSampol Mayol, AntoniaLopez-Jimenez, JavierPerez-Simon, Jose AMartinez, CarmenDiez, Jose-LuisSpanish Hematopoietic Transplant2024-07-112024-07-112017-12Gallardo D, Bosch-Vizcaya A, Rodriguez-Romanos R, Santos N, Buno I, De la Camara R, et al. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches. Biol Blood Marrow Transplant. 2017 Dec;23(12):2042-7. Epub 2017 Aug 4.1083-8791http://hdl.handle.net/20.500.13003/17289http://hdl.handle.net/20.500.12105/20386Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P=.005; HR, 2.11, 95% CI, 1.06 to 4.18; P=.033; and HR, 1.50; 95% CI, 1.05 to 2.15; P=.025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.enghttp://creativecommons.org/licenses/by-nc-nd/4.0/CTLA-4Minor histocompatibility antigensGraft-versus-host diseaseAllogeneic transplantationChildGenotypeAgedCTLA-4 AntigenYoung AdultAdultHistocompatibilityHumansImmunityChild, PreschoolAdolescentMiddle AgedInfantGraft vs Host DiseaseTissue DonorsMinor Histocompatibility Antigensresearch articleAttribution-NonCommercial-NoDerivatives 4.0 International2882706423122042-204710.1016/j.bbmt.2017.08.0031523-6536Biology of Blood and Marrow Transplantationopen accessAntígenos de Histocompatibilidad MenorEnfermedad Injerto contra HuéspedDonantes de TejidosLactanteAdolescenteInmunidadPreescolarHistocompatibilidadHumanosPersona de Mediana EdadAdulto JovenAncianoGenotipoNiñoAdultoAntígeno CTLA-42-s2.0-85028624003418309000005L618107562