Villanueva, Andrea APuvogel, SofíaLois, PabloMuñoz-Palma, ErnestoRamírez Orellana, ManuelLubieniecki, FabianaCasco Claro, FernandoGallegos, IvánGarcia-Castro, JavierSánchez-Gómez, PilarTorres, Vicente APalma, Verónica2019-07-112019-07-112018Cell Adh Migr. 2019 Dec;13(1):33-401933-6918http://hdl.handle.net/20.500.12105/7895Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells.engVoRhttp://creativecommons.org/licenses/by/4.0/Laminin γ1Neogenin-1Netrin-4NeuroblastomaBasal laminaCell adhesionCell migrationAtribución 4.0 Internacional301601931314010.1080/19336918.2018.15066521933-6926Cell Adhesion & Migrationopen access